1034706-81-4 Usage
Description
(+)-N-Acetyl 3,4,4a,5,6,10b-Hexahydro-2H-naphtho[1,2-β][1,4]oxazine-9-ol Triisopropylsilyl Ether is a pale yellow oil that serves as a precursor for the synthesis of radiolabeled amines. These radiolabeled amines are valuable in the field of medical imaging, particularly for neuro-receptor imaging using radiolabeled agonists.
Uses
Used in Medical Imaging Industry:
(+)-N-Acetyl 3,4,4a,5,6,10b-Hexahydro-2H-naphtho[1,2-β][1,4]oxazine-9-ol Triisopropylsilyl Ether is used as a precursor for the preparation of radiolabeled amines for Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT). These imaging techniques are essential for visualizing neuro-receptors and studying their functions in various neurological conditions and diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 1034706-81-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,4,7,0 and 6 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1034706-81:
(9*1)+(8*0)+(7*3)+(6*4)+(5*7)+(4*0)+(3*6)+(2*8)+(1*1)=124
124 % 10 = 4
So 1034706-81-4 is a valid CAS Registry Number.
1034706-81-4Relevant articles and documents
Synthesis of the dopamine D2/D3 receptor agonist (+)-PHNO via supercritical fluid chromatography: Preliminary PET imaging study with [3-11C]-(+)PHNO
Shoup, Timothy M.,McCauley, John P.,Lee Jr., David F.,Chen, Rui,Normandin, Marc D.,Bonab, Ali A.,El Fakhri, Georges,Vasdev, Neil
, p. 682 - 685 (2014/01/23)
Carbon-11 labeled (+)-4-[1-11C]propyl-3,4,4a,5,6,10b-hexahydro- 2H-naphtho[1,2-b][1,4]oxazin-9-ol ([1-11C]-(+)-PHNO) is a dopamine D3-preferring agonist radiopharmaceutical used for medical imaging by positron emission tomography (PET). We report the synthesis of (+)-PHNO using supercritical fluid chromatography for enantiomeric resolution of its norpropyl derivative, HNO, followed by propylation. (+)-HNO was used to prepare the radiolabeling precursor, (+)-trans-4-acetyl-9-triisopropylsilyloxy-2,3,4a,5,6, 10b-hexahydro-4H-naphth[1,2b][1,4]oxazine, in 12 steps. Modifications to the labeling procedure were made to ensure consistent preparation of [3- 11C]-(+)-PHNO via [11C]CH3I. A preliminary PET imaging study was carried out with this tracer in an attempt to image dopamine receptors in brown adipose tissue (brown fat) in vivo.