103574-68-1Relevant articles and documents
Identification of potent type I MetAPs inhibitors by simple bioisosteric replacement. Part 2: SAR studies of 5-heteroalkyl substituted TCAT derivatives
Cui, Yong-Mei,Huang, Qing-Qing,Xu, Jie,Chen, Ling-Ling,Li, Jing-Ya,Ye, Qi-Zhuang,Li, Jia,Nan, Fa-Jun
, p. 4130 - 4135 (2007/10/03)
Systematic SAR studies on the thiazole ring 5-substituent of TCAT derivatives revealed that the introduction of a β-alkoxy or an amino group enhanced the inhibitory activity significantly. The present compounds are representative of specific Co(II)-MetAP1 inhibitors. Before the physiologically relevant metal ions for MetAPs are established, these small molecular compounds could be used as tools for detailed biological studies.
ASYMMETRIC REDUCTION OF PROCHIRAL HYDROXY KETONES WITH A CHIRAL REDUCING AGENT PREPARED FROM TIN(II) CHLORIDE, A CHIRAL DIAMINE, AND DIISOBUTYLALUMINUM HYDRIDE
Mukaiyama, Teruaki,Tomimori, Koji,Oriyama, Takeshi
, p. 1359 - 1362 (2007/10/02)
Asymmetric reduction of prochiral α- and β-hydroxy ketones with a reagent, generated from tin(II) chloride, a chiral diamine, and diisobutylaluminum hydride, afforded the corresponding dihydroxy compounds in good chemical and optical yields.Optical yields depended on the nature of the protective groups of hydroxyl function.
