1036990-42-7

Basic information

• Product Name: 2-(TRIFLUOROMETHYL)PYRIDINE-4-BORONIC ACID PINACOL ESTER
• Synonyms: 2-(TRIFLUOROMETHYL)PYRIDINE-4-BORONIC ACID PINACOL ESTER;4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-2-(TRIFLUOROMETHYL)PYRIDINE;PYRIDINE, 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-2-(TRIFLUOROMETHYL)-;2-(trifluoroMethyl)-4-(4;4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)pyridine, 4,4,5,5-Tetramethyl-2-[2-(trifluoromethyl)pyridin-4-yl]-1,3,2-dioxaborolane;2-(trifluoromethyl)pyridin-4-ylboronic acid pinacol ester;3-hydroxy-2,3-dimethylbutan-2-yl hydrogen (2-(trifluoromethyl)pyridin-4-yl)boronate;2-Trifluoromethyl-4-pyridineboronic acid pinacol ester
• CAS NO: 1036990-42-7
• Molecular Formula: C₁₂H₁₅BF₃NO₂
• Molecular Weight: 291.0744896
• Mol File: 1036990-42-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 349.277 °C at 760 mmHg
• Flash Point: 165.037 °C
• Appearance: /
• Density: 1.18
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: -0.29±0.22(Predicted)
• CAS DataBase Reference: 2-(TRIFLUOROMETHYL)PYRIDINE-4-BORONIC ACID PINACOL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(TRIFLUOROMETHYL)PYRIDINE-4-BORONIC ACID PINACOL ESTER(1036990-42-7)
• EPA Substance Registry System: 2-(TRIFLUOROMETHYL)PYRIDINE-4-BORONIC ACID PINACOL ESTER(1036990-42-7)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN2811
• Hazardous Substances Data: 1036990-42-7(Hazardous Substances Data)

Usage

General Description

2-(Trifluoromethyl)pyridine-4-boronic acid pinacol ester is a synthetic chemical compound commonly used in the field of organic chemistry. It is a boronic acid derivative with a pinacol ester group and a trifluoromethyl substituent on the pyridine ring. 2-(TRIFLUOROMETHYL)PYRIDINE-4-BORONIC ACID PINACOL ESTER is often utilized as a reagent in the Suzuki-Miyaura cross-coupling reaction, which is a widely used method for the formation of carbon-carbon bonds in organic synthesis. It is also used as a building block for the synthesis of various pharmaceuticals, agrochemicals, and other fine chemicals. Additionally, its unique structure and reactivity make it a valuable tool for the development of new chemical reactions and methodologies in the field of organic synthesis.

Upstream product

• 39971-65-8 bis(((trifluoromethyl)sulfinyl)oxy)zinc 
• 368-48-9 2-(trifluoromethyl)pyridine 
• 73183-34-3 bis(pinacol)diborane 
• 887583-90-6 4-bromo-2-(trifluoromethyl)pyridine 
• 147149-98-2 2-(trifluoromethyl)pyridin-4-amine 
• 590371-73-6 2-(trifluoromethyl)pyridine-4-iodide 

Downstream Products

• 1353754-66-1 (6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl {4-[2-(trifluoromethyl)pyridin-4-yl]phenyl}carbamate 
• 1353754-51-4 1-[(6S)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl]-3-{4-[2-(trifluoromethyl)pyridin-4-yl]phenyl}urea 
• 1605962-37-5 4-[[5-methoxy-2-[4-(trifluoromethyl)phenyl]-2H-1,2,3-triazol-4-yl]methyl]-2-(trifluoromethyl)pyridine 
• 1605956-38-4 4-[[2-(2,4-difluorophenyl)-5-methyl-2H-1,2,3-triazol-4-yl]methyl]-2-(trifluoromethyl)pyridine 

Relevant articles and documents

NEW COMPOUNDS FOR TREATMENT OF DISEASES RELATED TO DUX4 EXPRESSION

The present invention relates to compounds for the treatment of diseases related to DUX4 expression, such as muscular dystrophies. It also relates to use of such compounds, or to methods of use of such compounds.

HERBICIDAL PYRIDINIUM COMPOUNDS

Compounds of the formula (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially as herbicides.

Iridium-catalyzed C-H borylation of pyridines

The iridium-catalysed C-H borylation is a valuable and attractive method for the preparation of aryl and heteroaryl boronates. However, application of this methodology for the preparation of pyridyl and related azinyl boronates can be challenged by low reactivity and propensity for rapid protodeborylation, particularly for a boronate ester ortho to the azinyl nitrogen. Competition experiments have revealed that the low reactivity is due to inhibition of the active catalyst through coordination of the azinyl nitrogen lone pair at the vacant site on the iridium. This effect can be overcome through the incorporation of a substituent at C-2. Moreover, when this is sufficiently electron-withdrawing protodeborylation is sufficiently slowed to permit isolation and purification of the C-6 boronate ester. Following functionalization, reduction of the directing C-2 substituent provides the product arising from formal ortho borylation of an unhindered pyridine ring. This journal is the Partner Organisations 2014.