1039646-91-7 Usage
Description
D/L-Di-p-toluoyl-tartaric acid, also known as D/L-(+/-)-Di-p-toluoyl-tartaric acid, is a chiral compound that consists of two enantiomers (D and L). It is a crystalline solid that is insoluble in water but soluble in organic solvents such as ethanol and acetone. D/L-Di-p-toluoyl-tartaricacid is commonly used as a resolving agent in the separation of racemic mixtures and is a valuable tool in the field of asymmetric synthesis and chiral resolution due to its ability to selectively crystallize with one enantiomer.
Uses
Used in Pharmaceutical Industry:
D/L-Di-p-toluoyl-tartaric acid is used as a resolving agent for the separation of racemic mixtures in the synthesis of chiral pharmaceuticals. Its selective crystallization with one enantiomer allows for the production of optically active intermediates, which are essential for the development of single-enantiomer drugs with improved efficacy and reduced side effects.
Used in Agrochemical Industry:
In the agrochemical industry, D/L-Di-p-toluoyl-tartaric acid serves as a resolving agent in the synthesis of chiral agrochemicals. The separation of enantiomers is crucial for creating more effective and environmentally friendly pesticides and herbicides, as only one enantiomer may be biologically active while the other may be inactive or even harmful.
Used in Asymmetric Synthesis:
D/L-Di-p-toluoyl-tartaric acid is utilized as a chiral auxiliary in asymmetric synthesis, a technique employed to produce enantiomerically pure compounds. Its ability to selectively interact with one enantiomer aids in the creation of chiral centers in target molecules, which is vital for the production of biologically active compounds with specific stereochemistry.
Used in Chiral Resolution:
D/L-Di-p-toluoyl-tartaric acid is used as a chiral resolving agent in the resolution of racemic mixtures. This process is essential for obtaining pure enantiomers, which can exhibit different biological activities and properties. The separation of enantiomers is particularly important in the fields of pharmaceuticals and agrochemicals, where the desired activity often resides in only one enantiomer.
Check Digit Verification of cas no
The CAS Registry Mumber 1039646-91-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,9,6,4 and 6 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1039646-91:
(9*1)+(8*0)+(7*3)+(6*9)+(5*6)+(4*4)+(3*6)+(2*9)+(1*1)=167
167 % 10 = 7
So 1039646-91-7 is a valid CAS Registry Number.
1039646-91-7Relevant articles and documents
Method for preparing D/L-di(p-toluoyl)tartaric acid
-
Paragraph 0020; 0025; 0026, (2017/06/20)
The invention discloses a method for preparing D/L-di(p-toluoyl)tartaric acid, and relates to the technical field of production and processing of di(p-toluoyl)tartaric acid. The main reactions of D/L-di(p-toluoyl)tartaric acid are shown in the specification and include the esterification reaction, centrifuging/washing, hydrolysis, cooling crystallization, centrifuging, drying, recrystallization, centrifuging and drying. The method for preparing D/L-di(p-toluoyl)tartaric acid includes the steps that methylbenzene and tartaric acid are put into an esterification kettle, p-toluoyl chloride and thionyl chloride are dropwise added, and di(p-toluoyl)tartaric anhydride is generated; water is added to hydrolyze the di(p-toluoyl)tartaric anhydride, cooling crystallization, centrifuging and drying are carried out, and a crude product is obtained; a methylbenzene/acetone mixed solvent is added into the crude product, recrystallization and centrifuging are carried out, the solid-phase substances are dried, and the finished product is obtained, wherein distilling recycling of the methylbenzene and the methylbenzene/acetone mixed solvent is carried out in a reaction kettle, condensation is achieved through water cooling and frozen saline water freezing, the recycled methylbenzene solvent is stored through an intermediate tank, and only a small amount of disordered exhaust gas is exhausted.
Indole derivatives
-
, (2008/06/13)
This invention is directed to a indole derivative represented by the general formula (1) STR1 wherein R1 stands for alkyl of 1 to 5 carbon atoms, cycloalkylalkyl of 4 to 7 carbon atoms, cycloalkenylalkyl of 5 to 7 carbon atoms, aralkyl of 7 to
