1040724-95-5

Basic information

• Product Name: C₁₄H₁₆BrN₃O₂
• Synonyms: C₁₄H₁₆BrN₃O₂
• CAS NO: 1040724-95-5
• Molecular Weight: 338.204
• Mol File: 1040724-95-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: C₁₄H₁₆BrN₃O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₄H₁₆BrN₃O₂(1040724-95-5)
• EPA Substance Registry System: C₁₄H₁₆BrN₃O₂(1040724-95-5)

Safety Data

• Hazardous Substances Data: 1040724-95-5(Hazardous Substances Data)

Upstream product

• 927-58-2 4-bromobutyroyl chloride 
• 1025447-42-0 5-(3-methoxy-phenyl)-2H-pyrazol-3-ylamine hydrochloride 
• 96799-04-1 5-(3-methoxyphenyl)-2H-pyrazol-3-ylamine 

Downstream Products

• 948880-69-1 4-azepan-1-yl-N-[5-(3-methoxy-phenyl)-1H-pyrazoI-3-yl]-butyramide 
• 948880-70-4 4-azepan-1-yl-N-[5-(3-methoxy-phenyl)-1H-pyrazol-3-yl]-butyramide formate 

Relevant articles and documents

N-[5-(5-fluoropyridin-3-yl)-1H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide (SEN78702, WYE-308775): A medicinal chemistry effort toward an α7 nicotinic acetylcholine receptor agonist preclinical candidate

α7 nicotinic acetylcholine receptors (α7 nAChR) represent promising therapeutic candidates for the treatment of cognitive impairment associated with Alzheimer's disease (AD) and schizophrenia. A medicinal chemistry effort around previously reported compound 1 (SEN15924, WAY-361789) led to the identification of 12 (SEN78702, WYE-308775) a potent and selective full agonist of the α7 nAChR that demonstrated improved plasma stability, brain levels, and efficacy in behavioral cognition models.

NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS

The present invention provides compounds of formula (I) and compositions thereof, methods of making them, and methods of using them to modulate alpha7 nicotinic acetylcholine receptors and/or to treat any of a variety of disorders, diseases, and conditions. Provided compounds can affect, among other things, neurological, psychiatric and/or inflammatory system.