104075-48-1 Usage
Description
1H-Imidazole, 4-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-, monohydrochloride is a synthetic compound characterized by its imidazole ring structure with a 2-ethyl-2,3-dihydro-1H-inden-2-yl group attached at the 4-position. The monohydrochloride form indicates the presence of a hydrochloric acid molecule, which provides a hydrogen ion for the compound. This structure is significant in various applications due to its unique chemical properties and interactions.
Uses
Used in Pharmaceutical Industry:
1H-Imidazole, 4-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-, monohydrochloride is used as an active pharmaceutical ingredient for its potential role in the development of drugs targeting specific receptors or enzymes. Its unique structure allows for the modulation of biological activities, making it a promising candidate for therapeutic applications.
Used in Veterinary Medicine:
In the veterinary field, 1H-Imidazole, 4-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-, monohydrochloride is used as a synthetic α2-adrenergic antagonist, specifically to reverse the sedative and analgesic effects of dexmedetomidine and medetomidine in dogs. This application is crucial for managing the anesthesia and recovery process in veterinary practice.
Used in Neurological Applications:
1H-Imidazole, 4-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-, monohydrochloride has been explored as a potential anti-Parkinsonian drug in humans. Its ability to interact with specific receptors in the nervous system makes it a candidate for the treatment of Parkinson's disease, a neurodegenerative disorder affecting movement and motor control.
Used in Drug Delivery Systems:
The compound may also be utilized in the development of drug delivery systems, where its unique chemical properties can be harnessed to improve the bioavailability, targeting, and overall efficacy of therapeutic agents. This application can lead to the creation of novel drug formulations with enhanced performance and reduced side effects.
Biological Activity
Selective α 2 -adrenergic receptor antagonist (K i values are 1.1, 1.0, 0.89, 1300 and 6500 nM for α 2A , α 2B , α 2C , α 1A and α 1B receptors respectively). Brain penetrant.
Veterinary Drugs and Treatments
Atipamezole is labeled for use as a reversal agent for medetomidine
and dexmedetomidine. It potentially
could be useful for reversal
of other alpha2-adrenergic agonists as well (e.g., amitraz, xylazine,
clonidine, tizanidine, brimonidine).
Check Digit Verification of cas no
The CAS Registry Mumber 104075-48-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,4,0,7 and 5 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 104075-48:
(8*1)+(7*0)+(6*4)+(5*0)+(4*7)+(3*5)+(2*4)+(1*8)=91
91 % 10 = 1
So 104075-48-1 is a valid CAS Registry Number.
InChI:InChI=1/C14H16N2.ClH/c1-2-14(13-9-15-10-16-13)7-11-5-3-4-6-12(11)8-14;/h3-6,9-10H,2,7-8H2,1H3,(H,15,16);1H
104075-48-1Relevant articles and documents
Preparation process of atipamezole hydrochloride
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Paragraph 0029; 0031; 0033; 0035; 0037, (2020/12/08)
The invention relates to the technical field of preparation of compounds, in particular to a preparation process of atipamezole hydrochloride. The preparation process comprises the following operationsteps: 1) reacting 4-(2-ethyl-2-indanone) imidazole and alkali in an organic solvent; 2) adding hydrazine hydrate into the reaction solution obtained in the step 1) to obtain atemeconazole; and 3) adding the atemeconazole obtained in the reaction 2) into concentrated hydrochloric acid for salifying to obtain atemeconazole hydrochloride. At present, the industrial synthesis of the atemeconazole hydrochloride in the prior art is low in yield and high in cost; the invention provides a brand-new preparation process of the atenomezole, which effectively improves the reaction efficiency, synthesizes the atenomezole with high selectivity, reduces byproducts, effectively reduces the discharge of waste water and waste gas and is beneficial to industrial production.
