1044904-10-0 Usage
Description
Topotecan-D6 is a deuterated analog of topotecan, a semisynthetic derivative of the natural product camptothecin. It is a DNA topoisomerase I inhibitor and is used as an internal standard for the quantification of topotecan by gas chromatography (GC) or liquid chromatography-mass spectrometry (LC-MS). Topotecan-D6 is a light yellow to greenish powder.
Uses
Used in Pharmaceutical Industry:
Topotecan-D6 is used as an internal standard for the quantification of topotecan in pharmaceutical analysis. It helps in the accurate measurement of topotecan levels in various formulations, ensuring the quality and efficacy of the drug.
Used in Cancer Treatment:
Topotecan, the parent compound of Topotecan-D6, is an antineoplastic agent that inhibits DNA topoisomerase I. It is used in the treatment of small-cell lung cancer and has shown cytotoxicity and DNA damage in various cancer cell lines, such as human MCF-7 breast and DU145 prostate cancer cells, and HT-29 human colon adenocarcinoma cells.
Used in Research and Development:
Topotecan-D6 serves as a valuable tool in research and development for the study of DNA topoisomerase I inhibitors and their potential applications in cancer therapy. It aids in understanding the mechanism of action, pharmacokinetics, and pharmacodynamics of topotecan and its analogs.
Check Digit Verification of cas no
The CAS Registry Mumber 1044904-10-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,4,4,9,0 and 4 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1044904-10:
(9*1)+(8*0)+(7*4)+(6*4)+(5*9)+(4*0)+(3*4)+(2*1)+(1*0)=120
120 % 10 = 0
So 1044904-10-0 is a valid CAS Registry Number.
