104587-51-1

Basic information

• Product Name: 2-PyrrolidineMethanol, 4-hydroxy-, hydrochloride (1:1), (2S,4R)-
• Synonyms: 2-PyrrolidineMethanol, 4-hydroxy-, hydrochloride (1:1), (2S,4R)-;2-prrolidineMethanol,4-hydroxy-,(2s,4r)hcl;(3R,5S)-5-HYDROXYMETHYL-3-PYRROLIDINOL;(2S,4R)-2-PyrrolidineMethanol, 4-hydroxy-, hydrochloride (1:1);(3R,5S)-5-(hydroxymethyl)pyrrolidin-3-ol
• CAS NO: 104587-51-1
• Molecular Formula: C₅H₁₁NO₂
• Molecular Weight: 117.14634
• Mol File: 104587-51-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 266.1±20.0 °C(Predicted)
• Appearance: /
• Density: 1.167±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 14.75±0.40(Predicted)
• CAS DataBase Reference: 2-PyrrolidineMethanol, 4-hydroxy-, hydrochloride (1:1), (2S,4R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PyrrolidineMethanol, 4-hydroxy-, hydrochloride (1:1), (2S,4R)-(104587-51-1)
• EPA Substance Registry System: 2-PyrrolidineMethanol, 4-hydroxy-, hydrochloride (1:1), (2S,4R)-(104587-51-1)

Safety Data

• Hazardous Substances Data: 104587-51-1(Hazardous Substances Data)

Usage

General Description

2-PyrrolidineMethanol, 4-hydroxy-, hydrochloride (1:1), (2S,4R)- is a compound made up of the hydrochloride salt of 2-PyrrolidineMethanol, 4-hydroxy-, which is in turn a derivative of pyrrolidine and methanol. 2-PyrrolidineMethanol, 4-hydroxy-, hydrochloride (1:1), (2S,4R)- is specifically the (2S,4R)-stereoisomer, indicating it has a specific spatial arrangement of its atoms. It is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds due to its unique structure and reactivity. Additionally, it may also have potential applications in the field of medicinal chemistry and drug development due to its biological activity and potential therapeutic properties.

Upstream product

• 17342-08-4 (S)-Pyroglutaminol 

Downstream Products

• 908340-25-0 10-(2,4-dimethoxybenzyl)-(R)-2-hydroxy-7-oxo-2,3,(S)-3a,4,7,10-hexahydro-1H-5-oxa-10,11,11b-triazacyclopenta[a]anthracene-8-carboxylic acid 
• 908340-26-1 10-(2,4-dimethoxybenzyl)-(S)-2-amino-7-oxo-2,3,(S)-3a,4,7,10-hexahydro-1H-5-oxa-10,11,11b-triazacyclopenta[a]anthracene-8-carboxylic acid 
• 908340-24-9 1-(2,4-dimethoxybenzyl)-6-fluoro-7-[(R)-4-hydroxy-(S)-2-hydroxymethylpyrrolidin-1-yl]-4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxylic acid 
• 202127-41-1 1-(2-{(2S,4R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-pyrrolidin-1-yl}-2-oxo-ethyl)-5-methyl-1H-pyrimidine-2,4-dione 
• 202127-37-5 1-(2-{(2S,4R)-4-Hydroxy-2-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-pyrrolidin-1-yl}-2-oxo-ethyl)-5-methyl-1H-pyrimidine-2,4-dione 
• 202127-43-3 1-(2-{(2S,4R)-2-Hydroxymethyl-4-[(4-methoxy-phenyl)-diphenyl-methoxy]-pyrrolidin-1-yl}-2-oxo-ethyl)-5-methyl-1H-pyrimidine-2,4-dione 
• 344436-49-3 2-({4-[(2-Chloro-4-nitrophenyl)diazenyl]phenyl}ethylamino)ethyl (5S,3R)-3-hydroxy-5-(hydroxymethyl)pyrrolidinecarboxylate 
• 1056598-36-7 methyl 1-(2,4-dimethoxybenzyl)-6-fluoro-7-((2S,4R)-4-hydroxy-2-(hydroxymethyl)pyrrolidinyl)-4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxylate 
• 1315590-78-3 2-((2S,4R)-4-hydroxy-2-(hydroxymethyl)pyrrolidin-1-yl)-N-(4-((4-((5-methyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)thio)phenyl)acetamide 

Relevant articles and documents

Preparation method for L-hydroxyproline

The invention provides a preparation method for L-hydroxyproline. The preparation method comprises the following steps: preparing pyroglutamic acid; preparing pyroglutamate; preparing pyroglutamic acid alcohol; preparing (3R,7aS)-3-phenyltetrahydropyrrolo[1,2]oxazole-5(3H)-one; and preparing L-hydroxyproline. Compared with the prior art, the invention has the following beneficial effects: the method overcomes the problems that a traditional manner of extraction of L-hydroxyproline from an animal donor has potential safety hazards and that production of L-hydroxyproline is limited as biological raw materials are utilized, and can synthesize L-hydroxyproline under the condition of shortage of biological raw materials; synthetic methods for L-hydroxyproline are enriched; the added value of L-hydroxyproline is increased; the application scope of L-hydroxyproline can be further broadened; prepared L-hydroxyproline is high in yield and purity, so the synthesis purity of atazanavir is indirectly improved; and common raw materials can be selected in preparation of L-hydroxyproline, so production cost is low.