104727-52-8Relevant articles and documents
SOLVENT AND TEMPERATURE DEPENDENT REGIOSELECTIVE REACTIONS BETWEEN 2-CHLORO-6-CYANOPYRIDINE AND ALIPHATIC ALCOHOLS
Elman, Bjoern
, p. 4941 - 4948 (2007/10/02)
Reaction of 2-chloro-6-cyanopyridine with aliphatic mono- and di-alcohols or ethylene glycols affords, depending on the reaction conditions, alkoxypyridines or imino ester pyridines or a mixture of both types of compounds.It is suggested that the product distribution is determined by the stability of an imidate anion formed as an intermediate.An improved synthesis of 2-chloro-6-cyanopyridine is also described.