104828-83-3Relevant articles and documents
A convenient, highly stereoselective, metal-free synthesis of chiral amines
Guizzetti, Stefania,Benaglia, Maurizio,Biaggi, Cinzia,Celentano, Giuseppe
supporting information; experimental part, p. 134 - 136 (2010/07/16)
A low cost, efficient, metal-free highly stereoselective reduction of ketimines to chiral amines was developed. Different imines bearing a very cheap and removable chiral auxiliary were reduced simply by trichlorosilane in the presence of N,N-dimethylformamide, often in quantitative yield and complete control of the absolute stereochemistry, to afford highly enantiomerically enriched amines. Georg Thieme Verlag Stuttgart.
NADH MODELS XXI. STEREOSELECTIVE REDUCTION OF CHIRAL IMINES WITH HANTZSCH ESTER
van Niel, Johannes C.G.,Pandit, Upendra K.
, p. 6005 - 6012 (2007/10/02)
Imines derived from p-substituted acetophenones and (+) R-1-phenylethylamine are reduced by 3,5-diethoxycarbonyl-2,6-dimethyl-1,4-dihydro-pyridine (Hantzsch ester), in acetonitrile, in the presence of magnesium perchlorate, to diastereomeric mixtures of t