1048364-00-6

Basic information

• Product Name: methyl 2-(bis(4-acetylbenzyl)amino)-4-methylthiazole-5-carboxylate
• Synonyms: methyl 2-(bis(4-acetylbenzyl)amino)-4-methylthiazole-5-carboxylate
• CAS NO: 1048364-00-6
• Molecular Weight: 436.532
• Mol File: 1048364-00-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 2-(bis(4-acetylbenzyl)amino)-4-methylthiazole-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(bis(4-acetylbenzyl)amino)-4-methylthiazole-5-carboxylate(1048364-00-6)
• EPA Substance Registry System: methyl 2-(bis(4-acetylbenzyl)amino)-4-methylthiazole-5-carboxylate(1048364-00-6)

Safety Data

• Hazardous Substances Data: 1048364-00-6(Hazardous Substances Data)

Upstream product

• 3829-80-9 2-amino-4-methylthiazole-5-carboxylic acid methyl ester 
• 51229-51-7 4-acetylbenzyl bromide 

Downstream Products

• 1048364-26-6 2-(bis(4-acetylbenzyl)amino)-4-methylthiazole-5-carboxylic acid 

Relevant articles and documents

Design, synthesis, and biological evaluation of antiviral agents targeting flavivirus envelope proteins

Flavivirus envelope proteins (E proteins) have been shown to play a pivotal role in virus assembly, morphogenesis, and infection of host cells. Inhibition of flavivirus infection of a host cell by means of a small molecule envelope protein antagonist is an attractive strategy for the development of antiviral agents. Virtual screening of the NCI chemical database using the dengue virus envelope protein structure revealed several hypothetical hit compounds. Bioassay results identified a class of thiazole compounds with antiviral potency in cell-based assays. Modification of these lead compounds led to a series of analogues with improved antiviral activity and decreased cytotoxicity. The most active compounds 11 and 36 were effective in the low micromolar concentration range in a cellular assay system.