104960-55-6 Usage
General Description
3-AMINO-6-PHENYL-4-(TRIFLUOROMETHYL)THIENO[2,3-B]PYRIDINE-2-CARBONITRILE, also known as T234, is a chemical compound with a thienopyridine structure. It is a potent and selective inhibitor of phosphodiesterase 10A (PDE10A), which is a key enzyme involved in the regulation of intracellular levels of cAMP and cGMP. PDE10A inhibitors have been investigated for their potential therapeutic applications in neuropsychiatric disorders such as schizophrenia and Huntington's disease. T234 has shown promising results in preclinical studies, demonstrating favorable pharmacokinetic properties and significant antipsychotic and antiparkinsonian effects. 3-AMINO-6-PHENYL-4-(TRIFLUOROMETHYL)THIENO[2,3-B]PYRIDINE-2-CARBONITRILE has the potential to be developed into a novel treatment for these neurological conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 104960-55-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,4,9,6 and 0 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 104960-55:
(8*1)+(7*0)+(6*4)+(5*9)+(4*6)+(3*0)+(2*5)+(1*5)=116
116 % 10 = 6
So 104960-55-6 is a valid CAS Registry Number.
InChI:InChI=1/C15H8F3N3S/c16-15(17,18)9-6-10(8-4-2-1-3-5-8)21-14-12(9)13(20)11(7-19)22-14/h1-6H,20H2
104960-55-6Relevant articles and documents
CYCLIZATION OF NITRILES. XVIII. SYNTHESIS AND SOME TRANSFORMATIONS OF 6-ARYL-4-TRIFLUOROMETHYL-3-CYANO-2(1H)-PYRIDINETHIONES
Rodinovskaya, L. A.,Sharanin, Yu. A.,Litvinov, V. P.,Shestopalov, A. M.,Promonenkov, V. K.,et al.
, p. 2230 - 2235 (2007/10/02)
The reaction of 3-benzoyl- and 3-(2-thenoyl)-1,1,1-trifluoroacetone and also of 1-benzoyl- and 1-(2-thenoyl)-2-(1-morpholino)-3,3,3-trifluoro-1-propenes with cyanothioacetamide provides a convenient method for the production of 6-phenyl- and 6-(2-thienyl)-4-trifluoromethyl-3-cyano-2(1H)-pyridine thiones, which are used in the synthesis of substituted 3-aminothienopyridines and other condensed heterocyclic systems.
