1051899-83-2

Basic information

• Product Name: 2-chloro-N-(3-chloro-2,4-difluorophenyl)pyrimidin-4-amine
• Synonyms: 2-chloro-N-(3-chloro-2,4-difluorophenyl)pyrimidin-4-amine
• CAS NO: 1051899-83-2
• Molecular Weight: 276.073
• Mol File: 1051899-83-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-chloro-N-(3-chloro-2,4-difluorophenyl)pyrimidin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-N-(3-chloro-2,4-difluorophenyl)pyrimidin-4-amine(1051899-83-2)
• EPA Substance Registry System: 2-chloro-N-(3-chloro-2,4-difluorophenyl)pyrimidin-4-amine(1051899-83-2)

Safety Data

• Hazardous Substances Data: 1051899-83-2(Hazardous Substances Data)

Upstream product

• 3934-20-1 2,6-Dichloropyrimidine 
• 2613-34-5 2,4-difluoro-3-chloro-aniline 

Downstream Products

• 1051899-84-3 2-chloro-N-(3-chloro-2,4-difluoro-phenyl)-N-methyl-pyrimidin-4-amine 
• 1051896-43-5 N'-(3-chloro-2,4-difluoro-phenyl)-N'-methyl-N-[3-(4-methylpiperazin-1-yl)-5-methylsulfonyl-phenyl]pyrimidine-2,4-diamine 
• 1051896-03-7 N'-(3-chloro-2,4-difluoro-phenyl)-N'-methyl-N-(3-morpholin-4-yl-5-thiomorpholin-4-yl-phenyI)pyrimidine-2,4-diamine 
• 1075215-57-4 N'-(3-chloro-2,4-difluorophenyl)-N-(4-chloro-6-morpholin-4-yl-pyridin-2-yl)-N'-methyl-pyrimidine-2,4-diamine 

Relevant articles and documents

Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors

Janus kinases (JAKs) have been demonstrated to be critical in cytokine signaling and have thus been implicated in both cancer and inflammatory diseases. The JAK family consists of four highly homologous members: JAK1-3 and TYK2. The development of small-m

N' - (PHENYL) -N- (MORPHOLIN-4-YL-PYRIDIN-2-YL) -PYRIMIDINE-2, 4-DIAMINE DERIVATIVES AS EPHB4 KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE CONDITIONS

The invention concerns pyrimidine com pounds of Formula (I), or a pharmaceutically acceptable salt thereof where A1, A2, A3, R1, n, R2, R3, and R4 are as defined in the descripti