10523-48-5Relevant articles and documents
ANODIC OXIDATION OF PYRONES AND RELATED COMPOUNDS
Iguchi, Masanobu,Nishiyama, Atsuko,Eto, Hideo,Yamamura, Shosuke
, p. 1323 - 1326 (1980)
Triacetic lactone, 4-hydroxycoumarins, and kojic acid derivative were subjected to anodic oxidation in MeOH containing LiClO4 or NaCN to afford the corresponding methoxy or cyano compounds.In a basic media, however, dipyrone and dicoumarol were produced from triacetic lactone and 4-hydroxycoumarin, respectively.The formation process of 3-methoxytriacetic lactone as well as of 3-cyanotriacetic lactone is also presented.
Functionalized 4-hydroxy coumarins: Novel synthesis, crystal structure and DFT calculations
Stefanou, Valentina,Matiadis, Dimitris,Melagraki, Georgia,Afantitis, Antreas,Athanasellis, Giorgos,Igglessi-Markopoulou, Olga,McKee, Vickie,Markopoulos, John
experimental part, p. 384 - 402 (2011/03/22)
A novel short-step methodology for the synthesis in good yields of functionalized coumarins has been developed starting from an activated precursor, the N-hydroxysuccinimide ester of O-acetylsalicylic acid. The procedure is based on a tandem C-acylation-c
Novel short-step synthesis of functionalized γ-phenyl-β- hydroxybutenoates and their cyclization to 4-hydroxycoumarins via the N-hydroxybenzotriazole methodology
Athanasellis, Giorgos,Melagraki, Georgia,Chatzidakis, Haralambos,Afantitis, Antreas,Detsi, Anastasia,Igglessi-Markopoulou, Olga,Markopoulos, John
, p. 1775 - 1782 (2007/10/03)
A novel method for the synthesis of functionalized 3-substituted 4-hydroxycoumarins is reported. C-Acylation compounds were derived from the reaction of the N-hydroxybenzotriazole ester of the functionalized acetyl salicylic acids and a variety of active methylene compounds and cyclized to the title compounds. The synthesis is simple and the compounds are produced in yields varying from 39 to 80%. The structure of the newly prepared C-acylation compounds was thoroughly studied through NMR spectroscopy for the first time in the literature.