10527-11-4

Basic information

• Product Name: 3-(4-hydroxyphenyl)-1,1,3-trimethylindan-5-ol
• Synonyms: 3-(4-hydroxyphenyl)-1,1,3-trimethylindan-5-ol;1,1,3-TRIMETHYL-3-(4'-HYDROXYPHENYL)-5-INDENE;bisphenol Indane;2,3-dihydro-3-[4-hydroxyphenyl)-1,1,3-trimethyl-1H-indenol;1-(4-Hydroxyphenyl)-1,3,3-trimethylindan-6-ol;1,1,3-Trimethyl-3-(4-hydroxyphenyl)-2,3-dihydro-1H-indene-5-ol;3-(4-Hydroxyphenyl)-1,1,3-trimethyl-5-indanol;5-Hydroxy-3-(4-hydroxyphenyl)-1,1,3-trimethylindan
• CAS NO: 10527-11-4
• Molecular Formula: C₁₈H₂₀O₂
• Molecular Weight: 268.3502
• EINECS: 234-085-2
• Mol File: 10527-11-4.mol
• Article Data: 7

Chemical Properties

• Melting Point: 194-195 °C
• Boiling Point: 423.8 °C at 760 mmHg
• Flash Point: 197.9
• Appearance: white powder
• Density: 1.135 g/cm³
• Vapor Pressure: 8.78E-08mmHg at 25°C
• Refractive Index: 1.597
• Storage Temp.: Amber Vial, -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 10.06±0.30(Predicted)
• Stability: Light Sensitive
• CAS DataBase Reference: 3-(4-hydroxyphenyl)-1,1,3-trimethylindan-5-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-hydroxyphenyl)-1,1,3-trimethylindan-5-ol(10527-11-4)
• EPA Substance Registry System: 3-(4-hydroxyphenyl)-1,1,3-trimethylindan-5-ol(10527-11-4)

Safety Data

• Hazardous Substances Data: 10527-11-4(Hazardous Substances Data)

Usage

Description

3-(4-Hydroxyphenyl)-1,1,3-trimethylindan-5-ol is a synthetic compound derived from Bisphenol A (B519495), which is a chemical utilized in the production of polycarbonate plastics. 3-(4-hydroxyphenyl)-1,1,3-trimethylindan-5-ol has been found to possess significant effects on various aspects of health, including reproductive health, body weight, and plasma LH levels in female Sprague-Dawley rats.

Uses

Used in Plastics Industry:
3-(4-Hydroxyphenyl)-1,1,3-trimethylindan-5-ol is used as a chemical intermediate for the manufacturing of polycarbonate plastics. Its role in this application is to contribute to the structural integrity and durability of the final plastic product.
Used in Pharmaceutical Research:
3-(4-hydroxyphenyl)-1,1,3-trimethylindan-5-ol is also used as a subject of pharmaceutical research due to its potential effects on reproductive health, body weight, and plasma LH levels in female Sprague-Dawley rats. The findings from such research could lead to the development of new drugs or therapies targeting these health aspects.
Used in Chemical Analysis:
3-(4-Hydroxyphenyl)-1,1,3-trimethylindan-5-ol can be employed in chemical analysis and testing to study its properties and potential interactions with other compounds. This information can be valuable for understanding its behavior in various applications and for identifying possible new uses.

InChI:InChI=1/C18H20O2/c1-17(2)11-18(3,12-4-6-13(19)7-5-12)16-10-14(20)8-9-15(16)17/h4-10,19-20H,11H2,1-3H3

Upstream product

• 3910-35-8 1,1,3-trimethyl-3-phenylindane 
• 74-93-1 methylthiol 
• 67-64-1 acetone 
• 108-95-2 phenol 
• 6156-18-9 2,2-bis(methylthio)propane 
• 98-83-9 isopropenylbenzene 
• 80-05-7 BPA 
• 940-71-6 2,2,4,4,6,6-hexachloro-1,3,5-triaza-2,4,6-triphosphorine 

Downstream Products

• 251450-83-6 pentanoic acid 1,1,3-trimethyl-3-(4-pentanoyloxy-phenyl)-indan-5-yl ester 
• 223791-49-9 butyric acid 3-(4-butyryloxy-phenyl)-1,1,3-trimethyl-indan-5-yl ester 
• 345656-52-2 butyric acid 3-(4-hydroxy-phenyl)-1,1,3-trimethyl-indan-5-yl ester 
• 210295-65-1 (R)-(+)-2,3-dihydro-3-(4'-hydroxyphenyl)-1,1,3-trimethyl-1H-inden-5-ol 
• 223791-50-2 Butyric acid 4-((S)-6-hydroxy-1,3,3-trimethyl-indan-1-yl)-phenyl ester 

Relevant articles and documents

Generation and synthetic uses of stable 4-[2-isopropylidene]-phenol carbocation from bisphenol A

(Equation Presented) Stable 4-[2-isopropylidene]-phenol carbocation, IPP cation 1, was generated readily by addition of bisphenol A in concentrated sulfuric acid at ambient temperature, and the cation could be used for facile syntheses of 4-isopropenyl phenol (IPP), IPP dimers, and spiro-bisphenol derivatives.

Oligomeric hydroxy-aryloxy phosphazene based on cyclic chlorophosphazenes

Reaction of hexachlorocyclotriphosphazene and a mixture of cyclic chlorophosphazene [NPCl2]n =3-8 with an excess of diphenylolpropane under different conditions affords corresponding oligomeric hydroxy-aryloxy phosphazenes, which were characterized by gas chromatography-mass spectrometry, laser mass spectrometry, 31P and 1H NMR spectroscopy. Side reactions was found with participation of decomposition products of diphenylolpropane. Pleiades Publishing, Ltd., 2013.

Production of spirobiindane (by machine translation)

PROBLEM TO BE SOLVED: To produce 6,6'-dihydroxy-3,3,3',3'-tetramethyl-1,1'-spirobiindanes from commercial raw material with high selectivity.SOLUTION: In a reaction step to produce a compound represented by (formula 1) from a compound represented by (formula 2) in a reactor, while water is removed in the presence of acetone, the spirobiindane compound represented by (formula 1) is produced, wherein R1-R6 and R7-R12 are independently, H, a hydroxyl group, a halogen atom, an alkyl group with C12 or less, or the like.

IMPROVED PROCESS FOR THE MANUFACTURE OF POLYPHENOLS

An improved process for the manufacture of a polyphenol compound such as bisphenol-A by introducing into a reaction zone a phenolic compound reactant, a carbonyl compound reactant, and a catalyst promoter comprising bismethylthiopropane added to the reaction system in certain specific locations, and reacting the ingredients within the reaction zone in the presence of an acid catalyst.