10557-01-4Relevant articles and documents
Disulfonimides versus phosphoric acids in br?nsted acid catalysis: The effect of weak hydrogen bonds and multiple acceptors on complex structures and reactivity
Rothermel, Kerstin,?abka, Matej,Hioe, Johnny,Gschwind, Ruth M.
, p. 13221 - 13231 (2019)
In Br?nsted acid catalysis, hydrogen bonds play a crucial role for reactivity and selectivity. However, the contribution of weak hydrogen bonds or multiple acceptors has been unclear so far since it is extremely difficult to collect experimental evidence
Direct Asymmetric Hydrogenation of N-Methyl and N-Alkyl Imines with an Ir(III)H Catalyst
Salomó, Ernest,Gallen, Albert,Sciortino, Giuseppe,Ujaque, Gregori,Grabulosa, Arnald,Lledós, Agustí,Riera, Antoni,Verdaguer, Xavier
supporting information, p. 16967 - 16970 (2018/12/14)
A novel cationic [IrH(THF)(P,N)(imine)] [BArF] catalyst containing a P-stereogenic MaxPHOX ligand is described for the direct asymmetric hydrogenation of N-methyl and N-alkyl imines. This is the first catalytic system to attain high enantioselectivity (up to 94% ee) in this type of transformation. The labile tetrahydrofuran ligand allows for effective activation and reactivity, even at low temperatures. Density functional theory calculations allowed the rationalization of the stereochemical course of the reaction.
Carbolithiation of N-alkenyl ureas and N-alkenyl carbamates
Lefranc, Julien,Minassi, Alberto,Clayden, Jonathan
supporting information, p. 628 - 632 (2013/05/21)
N-Alkenyl ureas and N-alkenyl carbamates, like other N-acyl enamines, are typically nucleophilic at their β-carbon. However, by incorporating an α-aryl substituent, we show that they will also undergo attack at the β-carbon by organolithium nucleophiles,
