10557-21-8Relevant articles and documents
Cobalt(II) Chloride Catalysed Coupling of Acetic Anhydride with Aldehydes. A Novel Synthesis of Asymmetrical 1,2-Diones
Ahmad, Saeed,Iqbal, Javed
, p. 692 - 693 (1987)
Cobalt(II) chloride in acetonitrile efficiently catalyses the coupling of acetic anhydride with various aldehydes to the corresponding 1,2-diones in very high yields.
Ozonolysis of Alkynes - A Flexible Route to Alpha-Diketones: Synthesis of AI-2
Alterman, Joshua L.,Halverson, Larry J.,Kraus, George A.,Stroud, Marissa Roghair,Vang, Dua X.
supporting information, p. 7424 - 7426 (2020/10/05)
A mild procedure for the low-temperature conversion of alkynes to diketones has been developed and employed in the synthesis of AI-2.
A simple synthetic route to enantiopure α-hydroxy ketone derivatives by asymmetric hydrogenation
Sun, Tian,Zhang, Xumu
supporting information, p. 3211 - 3215 (2013/01/15)
High enantioselectivities (up to 99% ee) have been observed for the catalytic asymmetric hydrogenation of the α-ketone enol acetates. DuanPhos has been proved to be the most effective ligand for this reaction. The high yield and enantioselectivity of the asymmetric hydrogenation of the α-ketone enol acetates represents a feasible synthetic route to important pharmaceutical building blocks: α-hydroxy ketones. Copyright
New synthetic strategy for high-enantiopurity N-protected α-amino ketones and their derivatives by asymmetric hydrogenation
Sun, Tian,Hou, Guohua,Ma, Miaofeng,Zhang, Xumu
supporting information; experimental part, p. 253 - 256 (2011/04/16)
Asymmetric hydrogenation of α-dehydroamino ketones catalyzed by a rhodium-chiral phosphorus ligand complex (up to 99% ee, 1000 TON), represents an efficient approach to chiral α-amino ketones. The reduction of α-amino ketones catalyzed by palladium on carbon (Pd/C) leads to amphetamine precursors with quantitative yield and no significant enantioselectivity loss.