10596-32-4 Usage
Description
Difluoromethylene diphosphonate is a phosphonic acid derivative that is characterized as a thick brown oil. It is known for its potential in the development of biologically active compounds, making it a valuable substance in the field of chemistry and pharmaceuticals.
Uses
1. Used in Pharmaceutical Industry:
Difluoromethylene diphosphonate is used as a key intermediate for the synthesis of biologically active compounds due to its unique chemical properties and reactivity.
2. Used in Chemical Research:
Difluoromethylene diphosphonate serves as a valuable compound in chemical research, particularly in the development of new drugs and pharmaceuticals, as well as in the study of its chemical behavior and interactions with other molecules.
3. Used in Drug Delivery Systems:
Similar to gallotannin, difluoromethylene diphosphonate can be employed in the development of novel drug delivery systems. Its unique properties may allow for improved delivery, bioavailability, and therapeutic outcomes when used in conjunction with various organic and metallic nanoparticles as carriers.
Check Digit Verification of cas no
The CAS Registry Mumber 10596-32-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,5,9 and 6 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 10596-32:
(7*1)+(6*0)+(5*5)+(4*9)+(3*6)+(2*3)+(1*2)=94
94 % 10 = 4
So 10596-32-4 is a valid CAS Registry Number.
InChI:InChI=1/CH4F2O6P2/c2-1(3,10(4,5)6)11(7,8)9/h(H2,4,5,6)(H2,7,8,9)
10596-32-4Relevant articles and documents
The effect of bisphosphonate acidity on the activity of a thymidylyltransferase
Beaton, Stephen A.,Jiang, Patricia M.,Melong, Jonathan C.,Loranger, Matthew W.,Mohamady, Samy,Veinot, Thomas I.,Jakeman, David L.
supporting information, p. 5473 - 5480 (2013/09/02)
Thymidylyltransferases (thymidine diphospho pyrophosphorylases) are nucleotidylyltransferases that play key roles in the biosynthesis of carbohydrate components within bacterial cell walls and in the biosynthesis of glycosylated natural products. They catalyze the formation of sugar nucleotides concomitant with the release of pyrophosphate. Protein engineering of thymidylyltransferases has been an approach for the production of a variety of non-physiological sugar nucleotides. In this work, we have explored chemical approaches towards modifying the activity of the thymidylyltransferase (Cps2L) cloned from S. pneumoniae, through the use of chemically synthesized 'activated' nucleoside triphosphates with enhanced leaving groups, or by switching the metal ion co-factor specificity. Within a series of phosphonate-containing nucleoside triphosphate analogues, thymidylyltransferase activity is enhanced based on the acidity of the leaving group and a Br?nsted-type analysis indicated that leaving group departure is rate limiting. We have also determined IC50 values for a series of bisphosphonates as inhibitors of thymidylyltransferases. No correlation between the acidity of the inhibitors (pKa) and the magnitude of enzyme inhibition was found. The Royal Society of Chemistry.
