10599-69-6Relevant articles and documents
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Ramonczai,Vargha
, p. 2737 (1950)
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Improved synthesis method of 6-methyl-2-ethyl-3-hydroxypyridine
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Paragraph 0020; 0021; 0023; 0024; 0026; 0027, (2021/05/01)
The invention discloses an improved synthesis method of 6-methyl-2-ethyl-3-hydroxypyridine, and belongs to the technical field of synthesis of medical intermediates. The method comprises the following steps: 1) reacting propionic anhydride with 2-methyl furan in the presence of a catalyst, washing with water after the reaction is finished, and performing reduced pressure distillation to obtain 5-methyl2-propionyl furan; and 2) mixing the 5-methyl-2-propionyl furan, ammonia water and p-toluenesulfonic acid, carrying out heating reaction, acidifying to be neutral, filtering to obtain a 6-methyl-2-ethyl-3-hydroxypyridine crude product, and recrystallizing to obtain a 6-methyl-2-ethyl-3-hydroxypyridine refined product. The raw materials are easy to obtain, common Lewis acid is added in the step (1), the reaction time is greatly shortened, the good yield is obtained, the acid aqueous solution obtained through washing in the step 1) is used for the acid adjusting process in the step 2), and the three-waste emission problem is basically solved; and 2) the reaction process is simple, a closed heating and pressurizing method is adopted, the raw materials react thoroughly, the yield is high, and the method is suitable for industrial production.
Process for producing 2-aceylfuran derivatives
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, (2008/06/13)
2-Acylfuran derivatives STR1 (R: alkyl, phenyl, etc.; R1 : H, alkyl) are prepared in high yield by reaction, in the presence of a boron trifluoride complex catalyst, of a furan compound STR2 (X: H, Cl, Br; Y: Cl, Br) or with RCOOH in the presence of (XYCHCO)2 O.