106128-89-6

Basic information

• Product Name: SENKTIDE
• Synonyms: [SUCCINYL-ASP6,ME-PHE8] SUBSTANCE P;SUCCINYL-(ASP6,N-ME-PHE8)-SUBSTANCE P (6-11);[SUCCINYL-ASP6 N-ME-PHE8]-SUBSTANCE P (6-11) (SENKTIDE);[SUCCINYL-ASP6,N-ME-PHE8]-SUBSTANCE P, FRAGMENT 6-11;SUCCINYL-ASP-PHE-ME-PHE-GLY-LEU-MET-NH2;SUCCINYL-ASP-PHE-(N-ME)PHE-GLY-LEU-MET-NH2;SUCCINYL-ASP-PHE-N-METHYL-PHE-GLY-LEU-MET-NH2;SUC-ASP-PHE-N-ME-PHE-GLY-LEU-MET-NH2
• CAS NO: 106128-89-6
• Molecular Formula: C40H55N7O11S
• Molecular Weight: 841.97
• Product Categories: Tachykinin receptor;peptide
• Mol File: 106128-89-6.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 1262.6 °C at 760 mmHg
• Flash Point: 717.4 °C
• Appearance: colorless/
• Density: 1.29 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: −20°C
• PKA: 4.23±0.10(Predicted)
• CAS DataBase Reference: SENKTIDE(CAS DataBase Reference)
• NIST Chemistry Reference: SENKTIDE(106128-89-6)
• EPA Substance Registry System: SENKTIDE(106128-89-6)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 106128-89-6(Hazardous Substances Data)

Usage

Description

Senktide is a potent and selective agonist of the neuromedin K3 (NK3) receptor, with an EC50 value of 0.5-3 nM. It exhibits less potency in agonizing the NK1 receptor (EC50 = 35 μM) and has no effect on the NK2 receptor. This peptide is primarily used in research settings to investigate the function and role of the NK3 receptor in various biological processes.

Uses

Used in Research Applications:
Senktide is used as a research tool for studying the action of the NK3 receptor in cells and animals. Its high selectivity and potency make it an ideal compound for investigating the specific functions and signaling pathways associated with the NK3 receptor.
Used in Pharmaceutical Industry:
Senktide is used as a lead compound in the development of drugs targeting the NK3 receptor. Its ability to selectively activate the NK3 receptor can help researchers understand the therapeutic potential of modulating this receptor in treating various diseases and conditions.
Used in Neuroscience Research:
In the field of neuroscience, Senktide is used to explore the role of the NK3 receptor in neuronal function and behavior. This can provide insights into the underlying mechanisms of neurological disorders and the development of novel therapeutic strategies.
Overall, Senktide is a valuable compound in various research and development applications, particularly in the study of the NK3 receptor and its associated biological processes.

InChI:InChI=1/C40H55N7O11S/c1-24(2)19-28(37(55)45-27(36(41)54)17-18-59-4)44-33(49)23-42-39(57)31(21-26-13-9-6-10-14-26)47(3)40(58)30(20-25-11-7-5-8-12-25)46-38(56)29(22-35(52)53)43-32(48)15-16-34(50)51/h5-14,24,27-31H,15-23H2,1-4H3,(H2,41,54)(H,42,57)(H,43,48)(H,44,49)(H,45,55)(H,46,56)(H,50,51)(H,52,53)/t27-,28-,29-,30-,31-/m0/s1