1061682-23-2Relevant articles and documents
AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS
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Paragraph 0148, (2014/02/16)
The present invention relates to compounds useful as inhibitors of Aurora protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.
DRUG DISCOVERY METHODS
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, (2011/11/12)
The present invention relates to drug discovery methods, particularly methods for assaying compounds for activity as Aurora kinase inhibitors. This invention also relates to a pharmacophore describing compounds that are able to promote a conformational ch
AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS
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Page/Page column 35-36, (2009/01/20)
The present invention relates to compounds useful as inhibitors of Aurora protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.Formula (I) or a pharmaceutically acceptable salt thereof, wherein: Ht is A,B,C,D,E wherein said Ht is optionally and independently substituted with R2 and R2', provided that Ht is not pyrazolyl or thiazolyl; X is CH, N, 0, or S; Y is CH, N, 0, or S; Q is -O-, -NR'-, -S-, -C(=O)-, or -C(R' )2-; Rx is H or F; Rγ is -Z-R10; R1 is T- (Ring D);