106302-03-8 Usage
Description
(3-ETHOXYCARBONYL-2-OXOPROPYL)TRIPHENYLPHOSPHONIUM CHLORIDE is an organic compound with the chemical structure featuring a central phosphonium cation attached to a triphphenyl group and a 3-ethoxycarbonyl-2-oxopropyl group. It is known for its reactivity and utility in various chemical reactions and synthesis processes.
Uses
Used in Pharmaceutical Industry:
(3-ETHOXYCARBONYL-2-OXOPROPYL)TRIPHENYLPHOSPHONIUM CHLORIDE is used as a reactant for the preparation of cyclic amidine-based inhibitors of β-secretase (BACE-1). These inhibitors play a crucial role in the development of drugs targeting Alzheimer's disease by reducing the formation of amyloid-beta peptides.
Used in Organic Chemistry:
(3-ETHOXYCARBONYL-2-OXOPROPYL)TRIPHENYLPHOSPHONIUM CHLORIDE is utilized as a reagent in Wittig reactions, which are widely employed for the synthesis of alkenes from aldehydes or ketones. (3-ETHOXYCARBONYL-2-OXOPROPYL)TRIPHENYLPHOSPHONIUM CHLORIDE contributes to the formation of various organic compounds with potential applications in the pharmaceutical, agrochemical, and materials science industries.
Used in Synthesis of Other Compounds:
(3-ETHOXYCARBONYL-2-OXOPROPYL)TRIPHENYLPHOSPHONIUM CHLORIDE is used as a reactant in dehydrochlorination and alkylation reactions. These reactions are essential for the synthesis of various organic compounds, including those with potential applications in the chemical, pharmaceutical, and materials industries.
Check Digit Verification of cas no
The CAS Registry Mumber 106302-03-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,6,3,0 and 2 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 106302-03:
(8*1)+(7*0)+(6*6)+(5*3)+(4*0)+(3*2)+(2*0)+(1*3)=68
68 % 10 = 8
So 106302-03-8 is a valid CAS Registry Number.
InChI:InChI=1/C24H24O3P.ClH/c1-2-27-24(26)18-20(25)19-28(21-12-6-3-7-13-21,22-14-8-4-9-15-22)23-16-10-5-11-17-23;/h3-17H,2,18-19H2,1H3;1H/q+1;/p-1
106302-03-8Relevant articles and documents
Structural, theoretical and multinuclear NMR study of mercury(II) complexes with a new ambidentate phosphorus ylide
Sabounchei, Seyyed Javad,Salehzadeh, Sadegh,Hosseinzadeh, Marjan,Bagherjeri, Fateme Akhlaghi,Khavasi, Hamid Reza
experimental part, p. 2486 - 2492 (2011/10/18)
The reaction of the new ambidentate ylide, Ph3PCHCOCH 2COOC2H5 (EAPPY), with HgX2 (X = Cl, Br and I) in equimolar ratios using methanol as the solvent leads to binuclear complexes of the type [EAPPY·H
Silyl enol ethers as new protecting groups for alkyl 4-halo-3-oxobutanoates; the preparation of pure (3-alkoxycarbonyl-2-oxopropyl)triphenylphosphonium salts
Moorhoff, Cornelis M.
, p. 1987 - 1995 (2007/10/03)
A new method has been developed for the preparation of pure (3-alkoxycarbonyl-2-oxopropyl)triphenyl-phosphonium salts 8. Alkyl 4-bromo-3-oxobutanoates and alkyl 4-chloro-3-oxobutanoates 7 are protected as the trimethylsilyl enol ethers prior to treatment of the resulting bromo(trimethylsilyl enol ether) esters 20c and 21c with triphenylphosphine in toluene and then addition of a little water to give pure (3-isopropoxycarbonyl-2-oxopropyl)triphenylphosphonium bromide 8c. Bromo(silyl enol ether) esters react more efficiently with triphenylphosphine than the chloro(silyl enol ether) esters. tert-Butyldimethylsilyl enol ethers of alkyl 4-bromo-3-oxobutanoates and alkyl 4-chloro-3-oxobutanoates 7 also react with triphenylphosphine. Protection of isopropyl 4-bromo-3-oxobutanoate 7c as the enol acetate followed by subsequent reaction with triphenylphosphine gives (Z)-(2-acetoxy-3-isopropoxycarbonylbut-2-enyl)triphenylphosphonium bromide 17.
