106449-56-3 Usage
Description
2'-Deoxyisoguanosine is a nucleoside derivative that plays a significant role in the field of molecular biology and biochemistry. It is structurally similar to the naturally occurring nucleoside deoxyguanosine but with a modified sugar moiety. This modification allows for unique interactions and properties that are useful in various applications.
Uses
Used in Molecular Biology and Biochemistry:
2'-Deoxyisoguanosine is used as a building block for the synthesis of Duplex DNA and DNA/RNA hybrids. It is particularly useful for the creation of DNA mismatch pairs, which are essential for studying the stability and structure of the DNA helix. The modified sugar moiety in 2'-Deoxyisoguanosine allows for the investigation of various aspects of DNA-protein interactions, DNA repair mechanisms, and the effects of DNA modifications on helix stability.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2'-Deoxyisoguanosine is utilized as a key component in the development of novel drugs targeting DNA-related processes. Its unique properties make it a valuable tool for designing drugs that can interact with DNA in specific ways, potentially leading to the development of new treatments for various diseases, including cancer and genetic disorders.
Used in Diagnostics:
2'-Deoxyisoguanosine is also employed in the development of diagnostic tools and assays that rely on the detection and analysis of DNA and RNA molecules. Its incorporation into synthetic nucleic acids can help improve the sensitivity and specificity of these diagnostic tests, enabling more accurate and reliable results in clinical and research settings.
Check Digit Verification of cas no
The CAS Registry Mumber 106449-56-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,6,4,4 and 9 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 106449-56:
(8*1)+(7*0)+(6*6)+(5*4)+(4*4)+(3*9)+(2*5)+(1*6)=123
123 % 10 = 3
So 106449-56-3 is a valid CAS Registry Number.
106449-56-3Relevant articles and documents
Oxidative damage to DNA constituents by iron-mediated Fenton reactions: The deoxyadenosine family
Chattopadhyaya, Rajagopal,Goswami, Bhaswati
, p. 394 - 406 (2012/11/13)
The effect of exposing 2′-deoxyadenosine (dA), 5′-dAMP, 3′-dAMP, dApA, dA(pdA)19, and poly(dA): oligo(dT) to iron/H2O2 in the presence and absence of ethanol or NADH has been studied. HPLC retention times, enzyme treatments, radiolabeled substrates, UV absorption spectra, and fast atom bombardment mass spectrometry (FABMS) have been used to distinguish 20 products arising from the reaction, of which 16 have been identified and four anomers proposed by comparison with earlier gamma radiation studies. The radical responsible for the reactions seems to be analogous to radiation-derived ·OH, has many products in common, but has some novel ones probably specific for Fenton-induced damage. Two new dimeric adducts arising from the generation of hydroxylamine at N7 and its subsequent condensation with two known sugar damage products, dR-adenine-N1-oxide, and two isomers of dR-FAPy arising from radical attacks at C4 and C5, may be considered novel in the present study. Unlike radiation-derived ·OH, the radical under study is difficult to eliminate due to its generation in the proximity of the substrate molecules. It is proposed that the iron binds to the phosphate group and generates the radical in its vicinity. Strand breaks in dA(pdA)11 resulting from the Fenton reaction are of two types, spontaneous and alkali-labile. Duplex DNA is less sensitive to attack by this radical, as its various degradation products are a subset of those obtained with monomer substrates and only dR-FAPy production is relatively enhanced for poly (dA): oligo (dT) as compared to those from other substrates. Copyright