106474-57-1

Basic information

• Product Name: Benzenamine, 2-chloro-N-(4-methylphenyl)-
• CAS NO: 106474-57-1
• Molecular Formula: C13H12ClN
• Molecular Weight: 217.698
• Mol File: 106474-57-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzenamine, 2-chloro-N-(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 2-chloro-N-(4-methylphenyl)-(106474-57-1)
• EPA Substance Registry System: Benzenamine, 2-chloro-N-(4-methylphenyl)-(106474-57-1)

Safety Data

• Hazardous Substances Data: 106474-57-1(Hazardous Substances Data)

Upstream product

• 106-38-7 para-bromotoluene 
• 533-17-5 N-(2-chlorophenyl)acetamide 
• 694-80-4 2-bromo-1-chlorobenzene 
• 106-49-0 p-toluidine 
• 95-50-1 1,2-dichloro-benzene 
• 615-41-8 2-iodochlorobenzene 
• 95-51-2 o-chloroaniline 
• 95-57-8 2-monochlorophenol 

Downstream Products

• 1451061-11-2 1-(2-chlorophenyl)-5-methylindoline-2,3-dione 
• 78307-59-2 1-(4-methyl-phenyl)-2-methyl-1H-indole 

Relevant articles and documents

N-heterocyclic carbene-Pd(II)-2-methyl-4,5-dihydrooxazole complex-catalyzed highly chemoselective mono-amination of dichlorobenzenes

The palladium-catalyzed chemoselective mono-amination of dichlorobenzenes was reported in this paper. Under the suitable conditions, all reactions involving the three isomers of dichlorobenzenes with various secondary and primary amines in the presence of

Palladium C-N bond formation catalysed by air-stable robust polydentate ferrocenylphosphines: A comparative study for the efficient and selective coupling of aniline derivatives to dichloroarene

The arylation of aniline derivatives with dichloroarenes under a low palladium content (below the currently used 5 to 10 mol%) was studied using nine different ferrocenylphosphine ligands, including the easily accessible 1,1′-bis(diphenylphosphino)ferrocene, DPPF. The electron-enriched air-stable tridentate ferrocenylpolyphosphine 1,2-bis(diphenylphosphino)- 1′-(diisopropylphosphino)-4-tert-butylferrocene, L5, employed in 2 mol% in combination with 1 mol% [PdCl(η3-C3H 5)]2 allows an efficient and selective coupling, while such demanding substrates currently induce chloroarene homocoupling and/or dehalogenation processes. The scope and limitation of the optimized system are explored, with a focus on electron-poor fluoroanilines (deactivated nucleophiles) and electron-rich methylated and methoxylated dichlorobenzenes (deactivated electrophiles). The Royal Society of Chemistry 2014.

A facile C-N bond formation: One-pot reaction of phenols and amines via smiles rearrangement

Diarylamines and arylalkylamines were synthesized in high yields from 2-chlorophenols and amines, activated by chloroacetyl chloride under microwave irradiation (20-60 min) or conventional thermal conditions (3-6 h). The key transformation is believed to