106531-51-5

Basic information

• Product Name: FURO[2,3-C]PYRIDIN-3(2H)-ONE HYDROCHLORIDE
• Synonyms: FURO[2,3-C]PYRIDIN-3(2H)-ONE HYDROCHLORIDE;Furo[2,3-c]pyridin-3-one hydrochloride;furo[2,3-c]pyridin-3(2H)-one hydrochloride（WS202103）
• CAS NO: 106531-51-5
• Molecular Formula: C7H5NO2.ClH
• Molecular Weight: 171.582
• Mol File: 106531-51-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: FURO[2,3-C]PYRIDIN-3(2H)-ONE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: FURO[2,3-C]PYRIDIN-3(2H)-ONE HYDROCHLORIDE(106531-51-5)
• EPA Substance Registry System: FURO[2,3-C]PYRIDIN-3(2H)-ONE HYDROCHLORIDE(106531-51-5)

Safety Data

• Hazardous Substances Data: 106531-51-5(Hazardous Substances Data)

Usage

General Description

FURO[2,3-C]PYRIDIN-3(2H)-ONE HYDROCHLORIDE is a chemical compound with the molecular formula C6H5NO·HCl. It is a heterocyclic organic compound with a furan ring fused to a pyridine ring, and a ketone functional group. FURO[2,3-C]PYRIDIN-3(2H)-ONE HYDROCHLORIDE is commonly used in the pharmaceutical industry as a building block for the synthesis of various biologically active molecules. It is also utilized in the production of drugs and other medical products due to its potential pharmacological properties. Additionally, Furo[2,3-c]pyridin-3(2H)-one hydrochloride may be used in chemical research and experimentation for its unique structural characteristics and reactivity.

Upstream product

• 106531-50-4 Ethyl 3-Hydroxyfuro<2,3-c>pyridine-2-carboxylate 
• 10128-71-9 3-hydroxyisonicotinic acid 
• 18343-02-7 Ethyl 2-(4-Ethoxycarbonyl-3-pyridyloxy) acetate 
• 18342-97-7 ethyl 3-hydroxyisonicotinate 

Downstream Products

• 106531-53-7 2,3-Dihydrofuro<2,3-c>pyridin-3-ol 
• 19539-50-5 furo<2,3-c>pyridine 
• 927807-04-3 3-(tert-butyldiphenylsilyloxy)furo[2,3-c]pyridine 
• 927806-76-6 2-p-Tolylfuro[2,3-c]pyridin-3-ol 

Relevant articles and documents

RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF

Compounds of Formulas (I), (IIA) and (IIIA) are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formulas (I), (IIA) and (IIIA) and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Furopyridines. V. A Simple Synthesis of Furopyridine and Its 2- and 3-Methyl Derivatives

A simple synthesis of furopyridine and its 2- and 3-methyl derivatives from ethyl 3-hydroxyisonicotinate (2) is described.The hydroxy ester 2 was O-alkylated with ethyl bromoacetate or ethyl 2-bromopropionate to give the diester 3a or 3b.Cyclization of compound 3a afforded ethyl 3-hydroxyfuropyridine-2-carboxylate (4) which was hydrolyzed and decarboxylated to give furopyridin-3(2H)-one (5a).Cyclization of 3b gave the 2-methyl derivative 5b.Reduction of 5a and 5b with sodium borohydride yielded the corresponding hydroxy derivative 6a and 6b, respectively, which were dehydrated with phosphoric acid to give furopyridine (7a) and its 2-methyl derivative 7b. 4-Acetylpyridin-3-ol (8) was O-alkylated with ethyl bromoacetate to give ethyl 2-(4-acetyl-3-pyridyloxy)acetate (9).Saponification of compound 9, and the subsequent intramolecular Perkin reaction gave 3-methylfuropyridine (10).Cyclization of 9 with sodium ethoxide gave 3-methylfuropyridine-2-carboxylic acid, which in turn was decarboxylated to give compound 10.