1065509-93-4Relevant articles and documents
Highly enantioselective organocatalytic conjugate addition of nitromethane to α,β-unsaturated aldehydes: Three-step synthesis of optically active baclofen
Zu, Liansuo,Xie, Hexin,Li, Hao,Wang, Jian,Wang, Wei
, p. 2660 - 2664 (2008/09/19)
An efficient, organocatalytic, highly enantioselective, conjugate addition reaction of nitromethane with α,β-unsaturated aldehydes has been developed. The process serves as the key step for a practical 3-step synthesis of chiral baclofen, an antispastic drug.