106615-46-7

Basic information

• Product Name: 4,6-Dimethoxy-2-(piperazin-1-yl)pyrimidine
• Synonyms: 1-(4,6-Dimethoxy-2-pyrimidinyl)piperazine;4,6-dimethoxy-2-(1-piperazinyl)Pyrimidine
• CAS NO: 106615-46-7
• Molecular Formula: C₁₀H₁₆N₄O₂
• Molecular Weight: 224.26
• Product Categories: pharmacetical
• Mol File: 106615-46-7.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 408.2°Cat760mmHg
• Flash Point: 200.7°C
• Appearance: /
• Density: 1.166g/cm³
• Vapor Pressure: 7.11E-07mmHg at 25°C
• Refractive Index: 1.529
• CAS DataBase Reference: 4,6-Dimethoxy-2-(piperazin-1-yl)pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-Dimethoxy-2-(piperazin-1-yl)pyrimidine(106615-46-7)
• EPA Substance Registry System: 4,6-Dimethoxy-2-(piperazin-1-yl)pyrimidine(106615-46-7)

Safety Data

• Hazardous Substances Data: 106615-46-7(Hazardous Substances Data)

Usage

General Description

4,6-Dimethoxy-2-(piperazin-1-yl)pyrimidine is a chemical compound with the molecular formula C10H14N4O2. It is a pyrimidine derivative that contains two methoxy groups and a piperazine ring. 4,6-Dimethoxy-2-(piperazin-1-yl)pyrimidine has potential applications in medicinal chemistry and drug development due to its interaction with biological targets. It may be used as a building block in the synthesis of various pharmaceuticals and bioactive compounds. Further research and studies are needed to fully understand the potential uses and properties of this chemical.

InChI:InChI=1/C10H16N4O2/c1-15-8-7-9(16-2)13-10(12-8)14-5-3-11-4-6-14/h7,11H,3-6H2,1-2H3

Upstream product

• 110-85-0 piperazine 
• 113583-35-0 4,6-dimethoxypyrimidin-2-yl methyl sulfone 
• 13223-25-1 2-chloro-4,6-dimethoxypyrimidine 
• 90905-46-7 4,6-dimethoxy-2-(methylsulfanyl)pyrimidine 
• 223519-85-5 1-acetyl-4-(4,6-difluoropyrimidin-2-yl)piperazine 

Relevant articles and documents

Design, Synthesis, Antifungal Activities and SARs of (R)-2-Aryl-4,5-dihydrothiazole-4-carboxylic Acid Derivatives

Based on the structure of natural product 2-aryl-4,5-dihydrothiazole-4-carboxylic acid, a series of novel (R)-2-aryl-4,5-dihydrothiazole-4-carboxylic acid derivatives were designed and synthesized. Their structures were characterized by 1H NMR, 13C NMR and HRMS. The single crystal structure of compound 9b was determined by X-ray diffraction analysis. The antifungal activities were evaluated for the first time. The bioassay results indicated that most compounds exhibited moderate to good antifungal activities. The antifungal activities of compound 13a (against Cercospora arachidicola Hori), 13d (against Alternaria solani), and 16e (against Cercospora arachidicola Hori) were 61.9%, 67.3% and 61.9%, respectively, which are higher than those of the commercial fungicides chlorothalonil and carbendazim. Moreover, compound 13d exhibited excellent antifungal activities against 7 kinds of the fungi tested (66.7%, 77.3%, 63.0%, 87.9%, 70.0%, 70.0% and 80.0% at 50 μg?mL). Therefore, 13d can be used as a new lead structure for the development of antifungal agents.

Synthesis and bioactivity of aripiprazole derivatives

Ten aripirazole (CAS 129722-12-9) derivatives were prepared and examined for dopamine receptor antagonist activity. The structures of these newly synthesized compounds were confirmed by their elemental analyses and by IR, 1H-NMR and mass spectra. It was demonstrated that all the new compounds have dopamine receptor antagonist activity to a certain extent. Three compounds showed more potent activity than aripiprazole. ECV · Editio Cantor Verlag.

Piperazine compounds and medicinal use thereof

The present invention relates to a piperazine compound of the formula wherein R1and R2are each hydrogen, halogen, lower alkyl, lower alkoxy, amino, substituted amino, nitro, hydroxy or cyano, R3, R4and R5are each hydrogen, halogen, lower alkyl, lower alkoxy, nitro, amino, substituted amino or hydroxy, R6and R7are each hydrogen, lower alkyl, lower alkyl substituted by halogen, aralkyl, acyl or lower acyl substituted by halogen, R8and R9are each hydrogen or lower alkyl, Y is lower alkylene and the like, and ring A is phenyl, pyrimidyl, thiazolyl, pyridyl, pyrazyl or imidazolyl, a pharmaceutically acceptable salt thereof and pharmaceutical agents containing these compounds. The compound of the present invention has superior TNF-α production inhibitory effect and/or IL-10 production promoting effect, and, since it is free of or shows only strikingly reduced expression of an effect on the central nervous system, the compound is useful as a highly safe and superior TNF-α production inhibitor an/or IL-10 production promoter and is useful as an agent for the prophylaxis or treatment of various diseases caused by abnormal TNF-α production, diseases curable with IL-10, such as chronic inflammatory diseases, acute inflammatory diseases, inflammatory diseases due to infection, autoimmune diseases, allergic diseases, and TNF-α mediated diseases.