106726-82-3

Basic information

• Product Name: 5-CYANO-3-PYRIDINECARBOXYLIC ACID METHYL ESTER
• Synonyms: 5-CYANO-3-PYRIDINECARBOXYLIC ACID METHYL ESTER;METHYL-5-CYANOPYRIDINE-3-CARBOXYLATE;Methyl 5-cyano-pyridin-3-carboxylate;5-Cyanonicotinic acid methyl ester
• CAS NO: 106726-82-3
• Molecular Formula: C₈H₆N₂O₂
• Molecular Weight: 162.15
• EINECS: 125-856-9
• Product Categories: Pyridine series
• Mol File: 106726-82-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 269.235 °C at 760 mmHg
• Flash Point: 116.629 °C
• Appearance: /
• Density: 1.256 g/cm³
• Vapor Pressure: 0.00734mmHg at 25°C
• Refractive Index: 1.535
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: -0.25±0.20(Predicted)
• CAS DataBase Reference: 5-CYANO-3-PYRIDINECARBOXYLIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CYANO-3-PYRIDINECARBOXYLIC ACID METHYL ESTER(106726-82-3)
• EPA Substance Registry System: 5-CYANO-3-PYRIDINECARBOXYLIC ACID METHYL ESTER(106726-82-3)

Safety Data

• Hazardous Substances Data: 106726-82-3(Hazardous Substances Data)

Usage

General Description

5-Cyano-3-pyridinecarboxylic acid methyl ester is a chemical compound with the formula C8H6N2O2. It is an ester of cyano-pyridinecarboxylic acid, and it is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. The compound is known to have antifungal and antibacterial properties, making it useful in the development of new medications. It is also used as a building block in the production of various fine chemicals and is widely employed in organic synthesis. Additionally, it has potential applications in research and development, particularly in the field of medicinal chemistry. Overall, 5-cyano-3-pyridinecarboxylic acid methyl ester is a versatile and valuable chemical with diverse uses in various industries.

InChI:InChI=1/C8H6N2O2/c1-12-8(11)7-2-6(3-9)4-10-5-7/h2,4-5H,1H3

Upstream product

• 557-21-1 dicyanozinc 
• 29681-44-5 5-bromo-3-pyridine carboxylic acid methyl ester 
• 544-92-3 copper(I) cyanide 
• 152803-05-9 5-ethynylnicotinonitrile 
• 20826-04-4 5-bromo-3-pyridinecarboxylic acid 

Downstream Products

• 106726-84-5 5-((4S,5S)-4-Methoxymethyl-5-phenyl-4,5-dihydro-oxazol-2-yl)-nicotinic acid methyl ester 
• 135124-71-9 5-(hydroxymethyl)pyridine-3-carbonitrile 
• 1154063-11-2 C₂₁H₁₄F₂N₄ 
• 1314890-79-3 N-(2-(2-(4-chlorophenyl)thiazol-4-yl)-2-methylpropyl)-5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)nicotinamide 
• 1314890-82-8 N-(2-(2-(4-chlorophenyl)thiazol-4-yl)ethyl)-5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)nicotinamide 
• 887579-62-6 5-cyano-3-pyridinecarboxylic acid 
• 1314890-37-3 N-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)-5-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)nicotinamide 

Relevant articles and documents

Application of polymer-supported triphenylphosphine and microwave irradiation to the palladium-catalyzed cyanation of aryl triflates

A variety of aryl nitriles were prepared in excellent yield from the palladium(II) acetate-catalyzed cross-coupling of aryl triflates and zinc cyanide under microwave irradiation conditions. To facilitate purification, polymer-supported triphenylphosphine was used as the palladium ligand. Comparison to the corresponding thermal conditions revealed much shorter reaction times with comparable yields. Copyright Taylor & Francis Group, LLC.

CB1 MODULATOR COMPOUNDS

Novel compounds of structural formula (I) are disclosed. As modulators of the Cannabinoid-1 (CB1) receptor, these compounds are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. As such, compounds of the present invention are useful as in the treatment, prevention and suppression of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders (e.g., multiple sclerosis, Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis), cerebral vascular accidents, head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, particularly to opiates, alcohol, and nicotine. The compounds are also useful for the treatment of obesity or eating disorders associated with excessive food intake and complications associated therewith.