106860-20-2

Basic information

• Product Name: CILAZAPRIL
• Synonyms: 1-(S)- cis 9-Aminooctahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid, t-butyl est;(1S cis) 9-Aminooctahydro-10-oxo-6Hpyridazino[1,2-a][1,2]diazepine-1-carboxylic acid, t-butyl ester;1-(S)-cis-9-Aminooctahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid tert-butyl ester
• CAS NO: 106860-20-2
• Molecular Formula: C₁₄H₂₅N₃O₃
• Molecular Weight: 435.518
• Mol File: 106860-20-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 598.1 °C at 760 mmHg
• Flash Point: 315.5 °C
• Appearance: /
• Density: 1.17
• PKA: 8.57±0.40(Predicted)
• CAS DataBase Reference: CILAZAPRIL(CAS DataBase Reference)
• NIST Chemistry Reference: CILAZAPRIL(106860-20-2)
• EPA Substance Registry System: CILAZAPRIL(106860-20-2)

Safety Data

• Hazardous Substances Data: 106860-20-2(Hazardous Substances Data)

Usage

General Description

Cilazapril is a medication belonging to the class of angiotensin-converting enzyme (ACE) inhibitors, used to treat high blood pressure and heart failure. It works by relaxing and widening blood vessels, which helps to lower blood pressure and improve the pumping ability of the heart. Cilazapril is also used to reduce the risk of heart attacks, strokes, and other complications in patients with high blood pressure and certain heart conditions. This medication is typically taken orally and is available in tablet form. As with any medication, cilazapril may have side effects and interactions with other drugs, so it is important to use it under the supervision of a healthcare professional.

Upstream product

• 106927-97-3 (1S,9S)-t-butyl octahydro-10-oxo-9-phthalimido-6H-pyridazino<1,2-a><1,2>diazepine-1-carboxylate 
• 88767-16-2 (S)-4-Chlorocarbonyl-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyric acid benzyl ester 
• 88767-18-4 (S,S)-5-(6-(tert-butoxycarbonyl)tetrahydropyridazin-1(2H)-yl)-4-(1,3-dioxoisoindolin-2-yl)-5-oxopentanoic acid 
• 106860-13-3 (S)-2-[(S)-4-Benzyloxycarbonyl-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyryl]-tetrahydro-pyridazine-1,3-dicarboxylic acid 1-benzyl ester 3-tert-butyl ester 
• 72064-51-8 (3S)-N¹-benzyloxycarbonyl-piperazic acid tert-butyl ester 
• 106928-72-7 (1S,9S)-t-butyl 1,2,3,4,7,8,9,10-octahydro-6,10-dioxo-9-phthalimidopyridazino<1,2-a><1,2>diazepine-1-carboxylate 
• 88784-33-2 (2S)-4-benzyloxicarbonyl-2-phthalimidobutanoic acid 

Downstream Products

• 106860-19-9 (1S,9S)-t-butyl 9-<(1S)-ethoxycarbonyl-3-phenylpropylamino>octahydro-10-oxo-6H-pyridazino<1,2-a><1,2>diazepine-1-carboxylate 
• 88768-40-5 cilazapril 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF AN INTERMEDIATE OF CILAZAPRIL

The present invention relates to a process for the preparation of optically pure (S,S)-6-t-butoxycarbonyl-hexahydro-1-pyridazinylcarbonyl-1,3-dioxo-2-isoindolebutyric acid, an intermediate for the preparation of cilazapril.