106942-44-3

Basic information

• Product Name: 4-(2,2-Difluoro-acetyl)-4-isobutyl-2-phenyl-4H-oxazol-5-one
• CAS NO: 106942-44-3
• Molecular Weight: 295.286
• Mol File: 106942-44-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2,2-Difluoro-acetyl)-4-isobutyl-2-phenyl-4H-oxazol-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2,2-Difluoro-acetyl)-4-isobutyl-2-phenyl-4H-oxazol-5-one(106942-44-3)
• EPA Substance Registry System: 4-(2,2-Difluoro-acetyl)-4-isobutyl-2-phenyl-4H-oxazol-5-one(106942-44-3)

Safety Data

• Hazardous Substances Data: 106942-44-3(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 401-67-2 2,2-difluoroacetic anhydride 
• 78007-41-7 4-(sec-butyl)-2-phenyloxazol-5(4H)-one 
• 4427-08-1 2-benzamido-3-methylpentanoic acid 

Relevant articles and documents

SYNTHESIS OF FLUORINATED α-AMINO KETONES PART I: α-BENZAMIDOALKYL MONO- DI- AND TRIFLUOROMETHYL KETONES

2-Phenyl-5(4H)-oxazolones, obtained from α-amino acids, are reacted with di- and trifluoro acetic anhydride by a modified Dakin-West procedure to yield in a one-pot reaction α-benzamidoalkyl-di- and trifluoromethyl ketones in good yields.The monofluoromethyl analogues were also prepared from α-amino acids, however the use of the highly toxic fluoroacetic anhydride was avoided.The key step is the halogen exchange reaction on the corresponding bromomethyl ketone.