107056-53-1

Basic information

• Product Name: Methanone, [1,1'-biphenyl]-4-ylcyclopropyl-
• CAS NO: 107056-53-1
• Molecular Formula: C16H14O
• Molecular Weight: 222.287
• Mol File: 107056-53-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Methanone, [1,1'-biphenyl]-4-ylcyclopropyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, [1,1'-biphenyl]-4-ylcyclopropyl-(107056-53-1)
• EPA Substance Registry System: Methanone, [1,1'-biphenyl]-4-ylcyclopropyl-(107056-53-1)

Safety Data

• Hazardous Substances Data: 107056-53-1(Hazardous Substances Data)

Upstream product

• 92-66-0 4-bromo-1,1'-biphenyl 
• 147356-78-3 cyclopropanecarboxylic acid N-methoxy-N-methylamide 
• 75-89-8 2,2,2-trifluoroethanol 
• 67-56-1 methanol 
• 1201-71-4 4-biphenyllithium 
• 5500-21-0 cyclopropropanecarbonitrile 

Relevant articles and documents

Silylium-Ion-Promoted (5+1) Cycloaddition of Aryl-Substituted Vinylcyclopropanes and Hydrosilanes Involving Aryl Migration

A transition-metal-free (5+1) cycloaddition of aryl-substituted vinylcyclopropanes (VCPs) and hydrosilanes to afford silacyclohexanes is reported. Catalytic amounts of the trityl cation initiate the reaction by hydride abstraction from the hydrosilane, and further progress of the reaction is maintained by self-regeneration of the silylium ions. The new reaction involves a [1,2] migration of an aryl group, eventually furnishing 4- rather than 3-aryl-substituted silacyclohexane derivatives as major products. Various control experiments and quantum-chemical calculations support a mechanistic picture where a silylium ion intramolecularly stabilized by a cyclopropane ring can either undergo a kinetically favored concerted [1,2] aryl migration/ring expansion or engage in a cyclopropane-to-cyclopropane rearrangement.

Mild Ring Contractions of Cyclobutanols to Cyclopropyl Ketones via Hypervalent Iodine Oxidation

An iodine-mediated oxidative ring contraction of cyclobutanols has been developed. The reaction allows the synthesis of a wide range of aryl cyclopropyl ketones under mild and eco-friendly conditions. A variety of functional groups including aromatic or alkyl halides, ethers, esters, ketones, alkenes, and even aldehydes are nicely tolerated in the reaction. This is in contrast with traditional synthetic approaches for which poor functional group tolerance is often a problem. The practicality of the method is also highlighted by the tunability of iodine oxidation system. Specifically, combining the iodine(III) reagent with an appropriate base allows the reaction to accommodate a range of challenging electron-rich arene substrates. The facile scalability of this reaction is also exhibited herein. (Figure presented.).