107416-49-9

Basic information

• Product Name: 2-phenyl-2-(piperidin-1-yl)acetic acid
• Synonyms: 2-phenyl-2-(piperidin-1-yl)acetic acid;alpha-Phenyl-1-piperidineacetic acid;2-Phenyl-2-(piperidin-1-yl)acetic acid hydrobromide
• CAS NO: 107416-49-9
• Molecular Formula: C₁₃H₁₇NO₂
• Molecular Weight: 219.27958
• Mol File: 107416-49-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 197-201℃
• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-phenyl-2-(piperidin-1-yl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-2-(piperidin-1-yl)acetic acid(107416-49-9)
• EPA Substance Registry System: 2-phenyl-2-(piperidin-1-yl)acetic acid(107416-49-9)

Safety Data

• Hazardous Substances Data: 107416-49-9(Hazardous Substances Data)

Usage

General Description

2-phenyl-2-(piperidin-1-yl)acetic acid, also known as PPA, is a chemical compound with the molecular formula C16H19NO2. It is a derivative of acetic acid and contains a phenyl group and a piperidine ring. PPA is commonly used as a pharmaceutical intermediate in the synthesis of various medications, including antipsychotic and antidepressant drugs. It has also been studied for its potential anti-inflammatory and anticonvulsant properties. PPA is a white to off-white crystalline powder and is typically used in research and development as well as in the production of pharmaceutical products.

Upstream product

• 7253-67-0 (R,S)-1-(1-piperidino)phenylacetamide 
• 23535-28-6 methyl 2-phenyl-2-(piperidin-1-yl)acetate 
• 7550-06-3 ethyl 2-phenyl-2-(piperidin-1-yl)acetate 
• 117-30-6 Dipiproverin 
• 110-89-4 piperidine 
• 298-12-4 Glyoxilic acid 
• 98-80-6 phenylboronic acid 
• 37167-62-7 bromo-phenyl-acetic acid methyl ester 
• 5766-79-0 2-phenyl-2-piperidinoacetonitrile 
• 7476-66-6 methyl 2-chloro-2-phenylethanoate 
• 4358-87-6 (RS)-methyl mandelate 
• 124-38-9 carbon dioxide 
• 2905-56-8 N-Benzylpiperidine 

Downstream Products

• 117-30-6 Dipiproverin 
• 479-81-2 AU₂₁₁₀₆ 
• 121970-60-3 methyl-bis-[2-(phenyl-piperidino-acetoxy)-ethyl]-amine 
• 23535-28-6 methyl 2-phenyl-2-(piperidin-1-yl)acetate 
• 897446-39-8 N-(2-aminophenyl)-2-phenyl-2-piperidin-1-ylacetamide 
• 31490-22-9 2-(phenyl-piperidin-1-yl-methyl)-1H-benzoimidazole 

Relevant articles and documents

Photoredox activation of carbon dioxide for amino acid synthesis in continuous flow

Although carbon dioxide (CO 2) is highly abundant, its low reactivity has limited its use in chemical synthesis. In particular, methods for carbon-carbon bond formation generally rely on two-electron mechanisms for CO 2 activation and require highly activated reaction partners. Alternatively, radical pathways accessed via photoredox catalysis could provide new reactivity under milder conditions. Here we demonstrate the direct coupling of CO 2 and amines via the single-electron reduction of CO 2 for the photoredox-catalysed continuous flow synthesis of α-Amino acids. By leveraging the advantages of utilizing gases and photochemistry in flow, a commercially available organic photoredox catalyst effects the selective α-carboxylation of amines that bear various functional groups and heterocycles. The preliminary mechanistic studies support CO 2 activation and carbon-carbon bond formation via single-electron pathways, and we expect that this strategy will inspire new perspectives on using this feedstock chemical in organic synthesis.

Synthesis and biological evaluation of benzimidazole derivatives as potent AMP-activated protein kinase activators

Design, synthesis and structure-activity relationships of benzimidazole derivatives as activators of the AMP-activated protein kinase (AMPK) are presented in this paper. AMPK is the central component of a protein kinase cascade that plays a key role in the regulation of energy balance. Once activated, AMPK initiates a series of responses that are aimed at restoring the energy balance of the cell and recent studies have indicated that AMPK plays an important role in regulation of the whole-body energy metabolism. The following study based on the lead compound S27847 involved modification of three regions of this compound. Preliminary structure-activity relationships are being described.