107618-13-3

Basic information

• Product Name: 4-(4-Methoxy-2-nitro-phenylamino)-piperidine-1-carboxylic acid ethyl ester
• Synonyms: 4-(4-Methoxy-2-nitro-phenylamino)-piperidine-1-carboxylic acid ethyl ester
• CAS NO: 107618-13-3
• Molecular Weight: 323.349
• Mol File: 107618-13-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(4-Methoxy-2-nitro-phenylamino)-piperidine-1-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-Methoxy-2-nitro-phenylamino)-piperidine-1-carboxylic acid ethyl ester(107618-13-3)
• EPA Substance Registry System: 4-(4-Methoxy-2-nitro-phenylamino)-piperidine-1-carboxylic acid ethyl ester(107618-13-3)

Safety Data

• Hazardous Substances Data: 107618-13-3(Hazardous Substances Data)

Upstream product

• 58859-46-4 ethyl 4-aminopiperidine-1-carboxylate 
• 61324-93-4 1-fluoro-nitro-4-methoxybenzene 
• 10298-80-3 2-chloro-5-methoxynitrobenzene 

Downstream Products

• 107618-20-2 4-(2-Amino-4-methoxy-phenylamino)-piperidine-1-carboxylic acid ethyl ester 

Relevant articles and documents

Discovery and SAR studies of a novel series of noncovalent cathepsin S inhibitors

A novel series of competitive, reversible cathepsin S (CatS) inhibitors was discovered and optimized. The 4-(2-keto-1-benzimidazolinyl)-piperidin-1-yl moiety was found to be an effective replacement for the 4-arylpiperazin-1-yl group found in our earlier series of CatS inhibitors. This replacement imparted improved PK properties as well as decreased off-target activity. Optimization of the ketobenzimidazole moiety led to the discovery of the lead compound JNJ 10329670, which represents a novel class of selective, noncovalent, reversible, and orally bioavailable inhibitors of cathepsin S.