107624-19-1

Basic information

• Product Name: 2-methyl-5-(phenylamino)phenol
• Synonyms: 2-methyl-5-(phenylamino)phenol
• CAS NO: 107624-19-1
• Molecular Weight: 199.252
• Mol File: 107624-19-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-methyl-5-(phenylamino)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-5-(phenylamino)phenol(107624-19-1)
• EPA Substance Registry System: 2-methyl-5-(phenylamino)phenol(107624-19-1)

Safety Data

• Hazardous Substances Data: 107624-19-1(Hazardous Substances Data)

Upstream product

• 591-50-4 iodobenzene 
• 2835-95-2 amino-4 hydroxy-2 toluene 
• 142-04-1 aniline hydrochloride 
• 16452-01-0 ortho-cresidine 

Downstream Products

• 1099831-89-6 2,2,8-trimethyl-N-phenyl-2H-chromen-5-amine 
• 23095-44-5 girinimbine 
• 27300-29-4 3',3'-dimethylpyrano[3,2-a]carbazole-3-carbaldehyde 

Relevant articles and documents

"on Water" Promoted Ullmann-Type C-N Bond-Forming Reactions: Application to Carbazole Alkaloids by Selective N-Arylation of Aminophenols

The Ullmann-type cross coupling of a variety of aromatic, aliphatic amines with aryl halides is reported using a CuI-based catalytic system in combination with an easily accessible prolinamide ligand in aqueous media. The method is mild and tolerant to air, moisture, and a wide range of functional groups, providing a novel way to access a variety of aminated products. Secondary amines like heteroaromatic amines and nucleobases have also been used, affording the corresponding coupling products in good to excellent yields. Moreover, this method has been employed for chemoselective C-N arylation of aminophenols and further utilized for the synthesis of carbazole natural products, avoiding the protection and deprotection steps.