107755-78-2

Basic information

• Product Name: N-[3-(pyridin-3-yl)propionyl]-4-(4-diphenylmethyl-1-piperazinyl)butylamine
• CAS NO: 107755-78-2
• Molecular Weight: 456.631
• Mol File: 107755-78-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-[3-(pyridin-3-yl)propionyl]-4-(4-diphenylmethyl-1-piperazinyl)butylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-[3-(pyridin-3-yl)propionyl]-4-(4-diphenylmethyl-1-piperazinyl)butylamine(107755-78-2)
• EPA Substance Registry System: N-[3-(pyridin-3-yl)propionyl]-4-(4-diphenylmethyl-1-piperazinyl)butylamine(107755-78-2)

Safety Data

• Hazardous Substances Data: 107755-78-2(Hazardous Substances Data)

Upstream product

• 3724-19-4 3-pyridine propionic acid 
• 101620-10-4 4-(4-diphenyl-methyl-1-piperazinyl)butylamine 

Relevant articles and documents

Use of pyridyl amides as inhibitors of angiogenesis

The invention relates to the use of derivatives of Formula I in the manufacture of a pharmaceutical composition for the treatment of a mammal, in which inappropriate, excessive or undesirable angiogenesis has occurred, and to the prevention thereof.

ω-(3-pyridyl)alkenamide derivatives and anti-allergenic pharmaceutical compositions containing same

Compounds of the formula: STR1 wherein X is alkylene or --(CR6 =CR7)r -- wherein R6 is H, alkyl or phenyl, R7 is H, alkyl, cyano or phenyl, and r is 1 or 2; A is alkylene or alkylene interrupted by at least one double bond; R1 is H, halogen, alkyl, alkoxy, alkylthio, cycloalkyloxy, cycloalkylthio, alkoxycarbonyl, carboxy, phenyl, phenoxy, phenylthio, 3-pyridyloxy or 3-pyridylthio; R2 is H, hydroxy, alkanoyloxy or alkoxycarbonyloxy, or adjacent R1 and R2 may combine to form tetramethylene or --CH2 OCR8 R9 O-- (R8 and R9 are alkyl); R3 is H, alkyl or hydroxyalkyl; R4 is H or alkyl; R5 is phenyl, heteroaryl or --(CH2)m --CHR10 R11 (R10 is H or phenyl, R11 is phenyl or pyridyl and m is 0 to 2); p is 0 or 1; and q is 2 or 3; the phenyl group or moiety being optionally substituted, and a salt thereof, process for the preparation thereof, and pharmaceutical composition containing the same. Said compounds and salts thereof show excellent antiallergic activity mainly through 5-lipoxygenase inhibiting activity, antihistamine activity and/or inhibitory activity against chemical mediator release and useful for treatment of allergic diseases.