107940-74-9

Basic information

• Product Name: 2-(4-CHLOROANILINO)-1H-ISOINDOLE-1,3(2H)-DIONE
• Synonyms: 2-(4-CHLOROANILINO)-1H-ISOINDOLE-1,3(2H)-DIONE;2-[(4-chlorophenyl)amino]-2,3-dihydro-1H-isoindole-1,3-dione
• CAS NO: 107940-74-9
• Molecular Formula: C₁₄H₉ClN₂O₂
• Molecular Weight: 272.69
• Mol File: 107940-74-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-CHLOROANILINO)-1H-ISOINDOLE-1,3(2H)-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-CHLOROANILINO)-1H-ISOINDOLE-1,3(2H)-DIONE(107940-74-9)
• EPA Substance Registry System: 2-(4-CHLOROANILINO)-1H-ISOINDOLE-1,3(2H)-DIONE(107940-74-9)

Safety Data

• Hazardous Substances Data: 107940-74-9(Hazardous Substances Data)

Upstream product

• 85-44-9 phthalic anhydride 
• 1073-69-4 N-4-chlorophenylhydrazine 
• 1073-70-7 4-chlorophenylhydrazine hydrochloride 

Downstream Products

• 107940-82-9 2-<4-Chlorphenyl(1,3,5-tri-tert-butyl-4-oxo-2,5-cyclohexadien-1-yl)amino>-1H-isoindol-1,3(2H)-dion 
• 107940-78-3 2,2'-<1,2-Di(4-chlorphenyl)-1,2-hydrazindiyl>bis(1H-isoindol-1,3(2H)-dion) 
• 120722-87-4 C₁₁H₁₁ClNO₃ 
• 68763-82-6 2-(4-chlorophenyl)-2,3-dihydrophthalazine-1,4-dione 
• 1205-71-6 N-(4-chlorophenyl)aniline 
• 73006-78-7 5-chloro[1,1'-biphenyl]-2-amine 
• 262606-99-5 N-(N-4-chlorophenyl-N-phenylamino)phthalimide 
• 58263-75-5 N-(4-chloro-phenyl)-N-phenyl-hydrazine 
• 156453-05-3 3-(4'-chlorophenyl)phthalazinium-1-olate 

Relevant articles and documents

Phthalazinone pyrazoles as potent, selective, and orally bioavailable inhibitors of Aurora-A kinase

The inhibition of Aurora kinases in order to arrest mitosis and subsequently inhibit tumor growth via apoptosis of proliferating cells has generated significant discussion within the literature. We report a novel class of Aurora kinase inhibitors based upon a phthalazinone pyrazole scaffold. The development of the phthalazinone template resulted in a potent Aurora-A selective series of compounds (typically >1000-fold selectivity over Aurora-B) that display good pharmacological profiles with significantly improved oral bioavailability compared to the well studied Aurora inhibitor VX-680.

1,3-DIPOLAR CYCLOADDITION REACTIONS OF SOME 3-ARYL-PHTHALAZINIUM-1-OLATES

The participation of halogen substituted 3-aryl-phthalazinium-1-olates in cycloaddition reactions were studied with various olefinic and acetylenic dipolarophiles.The betaines gave the expected cycloadducts with vinyl acetate, vinyl phenyl ether, and viny