107973-15-9Relevant articles and documents
Amidation of esters with amino alcohols using organobase catalysis
Caldwell, Nicola,Campbell, Peter S.,Jamieson, Craig,Potjewyd, Frances,Simpson, Iain,Watson, Allan J. B.
, p. 9347 - 9354 (2014/12/11)
A catalytic protocol for the base-mediated amidation of unactivated esters with amino alcohol derivatives is reported. Investigations into mechanistic aspects of the process indicate that the reaction involves an initial transesterification, followed by an intramolecular rearrangement. The reaction is highly general in nature and can be extended to include the synthesis of oxazolidinone systems through use of dimethyl carbonate.
SYNTHESIS OF 2-ARYL AND 2-HETARYLOXAZOLES FROM THE OXAZOLINES AND OXAZOLIDINES
Belen'kii, L. I.,Cheskis, M. A.,Ryashentseva, M. A.
, p. 650 - 653 (2007/10/02)
Treatment of 2-phenyl-, 2-(2-furyl)-, and 2-(2-thienyl)oxazolines with nickel peroxide has been found to give, in addition to the dehydrogenation products (2-substituted oxazoles),the fragmentation products (amides of benzoic, furan-2-carboxylic, and thiophen-2-carboxylic acids).This fragmentation appears to give initially the nitriles, which are then converted into the amides by the nickel peroxide.Catalytic dehydrogenation of 2-phenyloxazoline gives low yields of 2-phenyloxazole, the principal product being benzonitrile.Treatment of the Schiff's bases obtained from ethanolamine and aldehydes (benzaldehyde, furfural, and thiophen-2-aldehyde) with nickel peroxide gives trace amounts of the oxazoles, the principal products being the aldehydes, with smaller amounts of the nitriles.
