1080-41-7

Basic information

• Product Name: Phosphonic acid, (2-oxocyclohexyl)-, diethyl ester
• CAS NO: 1080-41-7
• Molecular Formula: C10H19O4P
• Molecular Weight: 234.232
• Mol File: 1080-41-7.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Phosphonic acid, (2-oxocyclohexyl)-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonic acid, (2-oxocyclohexyl)-, diethyl ester(1080-41-7)
• EPA Substance Registry System: Phosphonic acid, (2-oxocyclohexyl)-, diethyl ester(1080-41-7)

Safety Data

• Hazardous Substances Data: 1080-41-7(Hazardous Substances Data)

Upstream product

• 589-57-1 diethyl phosphorylchloridite 
• 6651-36-1 1-(Trimethylsilyloxy)cyclohexene 
• 51595-54-1 1-Chlor-7-oxa-bicyclo<4.1.0>heptan 
• 122-52-1 triethyl phosphite 
• 108-94-1 cyclohexanone 
• 79-36-7 dichloroacethyl chloride 
• 93350-46-0 <2-Aethoxy-cyclohexen-(1)-yl-(1)>-phosphonsaeure-diaethylester 
• 153172-02-2 1-Methoxy-2-(diethoxyphsphoryl)cyclohexene 
• 874-23-7 2-acetylcyclohexanone 
• 762-04-9 phosphonic acid diethyl ester 
• 145932-20-3 C₁₀H₁₆Cl₂NOP 
• 670-80-4 4-cyclohexen-1-ylmorpholine 
• 4471-09-4 N-benzylcyclohexylimine 
• 2303-76-6 sodium diethyl phosphite 

Downstream Products

• 143618-71-7 1-Phenylspiro<2.5>octan-4-one 
• 93350-46-0 <2-Aethoxy-cyclohexen-(1)-yl-(1)>-phosphonsaeure-diaethylester 
• 103984-96-9 (1-methyl-2-oxo-cyclohexyl)-phosphonic acid diethyl ester 
• 153172-02-2 1-Methoxy-2-(diethoxyphsphoryl)cyclohexene 
• 193021-17-9 diethyl 1-cinnamyl-2-oxocyclohexylphosphonate 
• 1043959-33-6 diethyl (1S)-1-[(R)-(tert-butoxycarbonylamino)(phenyl)-methyl]-2-oxo-cyclohexanephosphonate 

Relevant articles and documents

Silver-Catalyzed Oxidative C(sp3)?P Bond Formation through C?C and P?H Bond Cleavage

The silver-catalyzed oxidative C(sp3)?H/P?H cross-coupling of 1,3-dicarbonyl compounds with H-phosphonates, followed by a chemo- and regioselective C(sp3)?C(CO) bond-cleavage step, provided heavily functionalized β-ketophosphonates. This novel method based on a readily available reaction system exhibits wide scope, high functional-group tolerance, and exclusive selectivity.

[2 + 2] cycloaddition of cyclic vinyl phosphonates with ketenes

Highly substituted cyclic β-alkoxyvinyl phosphonates underwent thermal [2+2] cycloaddition with activated ketenes to afford bicyclic phosphonates. Fragmentation of the central polarized bond of this bicyclic system occurred readily upon treatment with zin

Reaction of Diethyl Phosphorochloridite with Enolates: A General Method for Synthesis of β-Keto Phosphonates and α-Phosphono Esters through C-P Bond Formation

The reaction of ketone enolates with diethyl phosphorochloridite, followed by air oxidation of the intermediate reaction products, has proven to be a general and convenient method for preparation of β-keto phosphonates.Fourteen β-keto phosphonates have been prepared by this method, in an average yield greater than 60percent.This procedure also appears to be applicable to preparation of both α-phosphono aldehydes and α-phosphono esters.Although special precautions may be necessary to avoid aldol condensation during formation of aldehyde enolates, in two cases it was shown that the resulting enolates react readily with diethyl chlorophosphite.Finally, a set of five ethyl esters was converted to α-phosphono esters by this method.Yields of the α-phosphono esters are influenced by steric hindrance at the enolate carbon, but the average yield for this series was ca. 70percent.Because this synthetic method relies upon an electrophilic phosphorus reagent for formation of the C-P bond, it is complementary to the traditional Arbuzov synthesis.On the basis of the 21 examples presented here, it appears to be more widely applicable.