1083180-00-0 Usage
General Description
Thiazol-4-ylboronic acid pinacol ester is an organoboron compound that has a thiazole ring and a boronic acid functional group attached to a pinacol (2,3-dimethyl-2,3-butanediol) ester. It is commonly used in organometallic chemistry as a precursor for the synthesis of various biologically active molecules, pharmaceuticals, and agrochemicals. The boronic acid moiety allows for facile cross-coupling reactions with a variety of electrophiles, making it a valuable building block in organic synthesis. Additionally, the thiazole ring imparts unique chemical and biological properties to the molecule, making it a versatile and important reagent in modern synthetic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 1083180-00-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,8,3,1,8 and 0 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1083180-00:
(9*1)+(8*0)+(7*8)+(6*3)+(5*1)+(4*8)+(3*0)+(2*0)+(1*0)=120
120 % 10 = 0
So 1083180-00-0 is a valid CAS Registry Number.
1083180-00-0Relevant articles and documents
Identification of Piperidine-3-carboxamide Derivatives Inducing Senescence-like Phenotype with Antimelanoma Activities
Oh, Sangmi,Kwon, Do Yoon,Choi, Inhee,Kim, Young Mi,Lee, Ji Young,Ryu, Jiyoung,Jeong, Hangyeol,Kim, Myung Jin,Song, Rita
supporting information, p. 563 - 571 (2021/05/06)
This study evaluated the potential use of senescence-inducing small molecules in the treatment of melanoma. We screened commercially available small-molecule libraries with high-throughput screening and high-content screening image-based technology. Our findings showed an initial hit with the embedded N-arylpiperidine-3-carboxamide scaffold-induced senescence-like phenotypic changes in human melanoma A375 cells without serious cytotoxicity against normal cells. A focused library containing diversely modified analogues were constructed and examined to evaluate the structure-activity relationship of N-arylpiperidine-3-carboxamide derivatives starting from hit 1. This work identified a novel compound with remarkable antiproliferative activity in vitro and demonstrated the key structural moieties within.