108534-50-5Relevant articles and documents
Diastereoselective synthesis of α-tocopherol: A new concept for the formation of chromanols
Chapelat, Julien,Buss, Axel,Chougnet, Antoinette,Woggon, Wolf-D.
supporting information; experimental part, p. 5123 - 5126 (2009/05/30)
(Chemical Equation Presented) A diastereoselective synthesis of α-tocopherol 1 (93% de) was achieved via two key steps, (i) a highly diastereoselective Shi epoxidation of a trisubstituted alkene and (ii) an acid supported, "anti-Baldwin" epoxide ring opening under inversion of configuration leading to the 6-membered chromanol ring.