108665-95-8Relevant articles and documents
Synthesis of 2-nitroindoles via the Sundberg indole synthesis
Pelkey, Erin T.,Gribble, Gordon W.
, p. 5603 - 5606 (1997)
A three-step sequence has been developed for converting o-nitrobenzaldehydes into 2-nitroindoles. The key step involves the thermolysis of 2-(o-azidophenyl)nitroethylene (10) in xylenes which gives 2-nitroindole (4) in 54% yield, akin to the classic Sundberg indole synthesis. This procedure has also been utilized to synthesize 5,6-dimethoxy-2-nitroindole (14).
Convenient KI-catalyzed regioselective synthesis of 2-sulfonylindoles using water as solvent
Li, Hongjie,Wang, Xiaolong,Yan, Jie
supporting information, p. 4277 - 4280 (2017/07/11)
A convenient procedure is developed for the preparation of 2-sulfonylindoles from indoles and sodium sulfinates catalyzed by KI in water. This environmentally benign 2-sulfonylation of indoles proceeds efficiently under mild conditions, affording the products with high regioselectivity and in moderate to good yields.
A Sulfonylation Reaction: Direct Synthesis of 2-Sulfonylindoles from Sulfonyl Hydrazides and Indoles
Rahaman, Rajjakfur,Barman, Pranjit
supporting information, p. 684 - 690 (2017/03/21)
A metal-free synthesis of 2-sulfonylindole derivatives has been developed through a novel TBHP/I2-mediated coupling of C3/unsubstituted indoles with sulfonyl hydrazides. The reaction utilizes readily available starting materials under mild reaction conditions, providing an alternative and attractive approach to 2-sulfonylindoles with high yields. The developed synthetic procedure is suitable for both N-protected or unprotected indoles.