108837-76-9

Basic information

• Product Name: 2-p-anisidinomethyl-5-nitro-isoindoline-1,3-dione
• Synonyms: 2-p-anisidinomethyl-5-nitro-isoindoline-1,3-dione
• CAS NO: 108837-76-9
• Molecular Weight: 327.296
• Mol File: 108837-76-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-p-anisidinomethyl-5-nitro-isoindoline-1,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-p-anisidinomethyl-5-nitro-isoindoline-1,3-dione(108837-76-9)
• EPA Substance Registry System: 2-p-anisidinomethyl-5-nitro-isoindoline-1,3-dione(108837-76-9)

Safety Data

• Hazardous Substances Data: 108837-76-9(Hazardous Substances Data)

Upstream product

• 22546-83-4 N-hydroxymethyl-3-nitrophthalimide 
• 104-94-9 4-methoxy-aniline 
• 136918-14-4 phthalimide 
• 89-40-7 4-nitrophthalimide 
• 50-00-0 formaldehyd 

Relevant articles and documents

Isoindole-1,3-dione derivatives as RSK2 inhibitors: Synthesis, molecular docking simulation and SAR analysis

RSK2 (p90 ribosomal S6 kinase 2) is a serine/threonine kinase expressed in a variety of cancers. Molecular-targeted inhibition of RSK2 as a potential therapeutic strategy for human cancers has been documented. In this work, a series of isoindole-1,3-dione derivatives as novel RSK2 inhibitors were designed and synthesized from a hit discovered in our previous study. Some compounds were confirmed to be moderately potent RSK2 inhibitors with IC50 values of about 0.5 μM. Structure-activity relationship analysis and binding mode studies by molecular docking were performed.