108868-73-1

Basic information

• Product Name: ((S)-1-{1-[(1S,2S)-1-Cyclohexylmethyl-2-hydroxy-4-(4-methyl-pentanoylamino)-butylcarbamoyl]-2-thiazol-4-yl-ethylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester
• Synonyms: ((S)-1-{1-[(1S,2S)-1-Cyclohexylmethyl-2-hydroxy-4-(4-methyl-pentanoylamino)-butylcarbamoyl]-2-thiazol-4-yl-ethylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester
• CAS NO: 108868-73-1
• Molecular Weight: 699.955
• Mol File: 108868-73-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ((S)-1-{1-[(1S,2S)-1-Cyclohexylmethyl-2-hydroxy-4-(4-methyl-pentanoylamino)-butylcarbamoyl]-2-thiazol-4-yl-ethylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: ((S)-1-{1-[(1S,2S)-1-Cyclohexylmethyl-2-hydroxy-4-(4-methyl-pentanoylamino)-butylcarbamoyl]-2-thiazol-4-yl-ethylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester(108868-73-1)
• EPA Substance Registry System: ((S)-1-{1-[(1S,2S)-1-Cyclohexylmethyl-2-hydroxy-4-(4-methyl-pentanoylamino)-butylcarbamoyl]-2-thiazol-4-yl-ethylcarbamoyl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester(108868-73-1)

Safety Data

• Hazardous Substances Data: 108868-73-1(Hazardous Substances Data)

Upstream product

• 3674-06-4 Boc-Phe-ONSu 
• 108868-54-8 (3S,4S)-3-hydroxy-4-<(tert-butyloxycarbonyl)amino>-5-cyclohexylpentanenitrile 
• 108868-87-7 Boc-Phe-dl-(4-thiazolyl)alanine methyl ester 
• 100002-74-2 2-Amino-3-thiazol-4-yl-propionic acid methyl ester; hydrochloride 
• 108868-55-9 (3S,4S)-1-amino-3-hydroxy-4-<(tert-butyloxycarbonyl)amino>-5-cyclohexylpentane 
• 107202-61-9 (2R,3S)-3-(t-butoxycarbonylamino)-4-cyclohexyl-1,2-epoxybutane 
• 98105-42-1 (S)-2-(t-butoxycarbonylamino)-3-cyclohexyl-1-propanal 
• 38136-29-7 4-methylvaleroyl chloride 
• 14717-97-6 2-Amino-3-(4-thiazolyl)-propanoic acid 
• 108868-88-8 Boc-Phe-dl-(4-thiazolyl)alanine 
• 108868-60-6 (3S,4S)-1-<<(3-methylbutyl)carbonyl>amino>-3-hydroxy-4-<(tert-butyloxycarbonyl)amino>-5-cyclohexylpentane 

Relevant articles and documents

Novel Renin Inhibitors Containing Analogues of Statine Retro-Inverted at the C-Termini: Specificity at the P2 Histidine Site

Substituted 1,3- and 1,4-diamines were prepared from epoxides derived from Boc-leucine or Boc-cyclohexylalanine. These diamines were incorporated into renin inhibitors (IC50 = 4-1500 nM) replacing the Leu-Val scissile bond in small peptide analogues of angiotensinogen. Replacement of the P2 histidine imidazole with other heterocycles maintained or enhanced binding while changing the overall basicity of the inhibitor. Finally, substitution of O-methyltyrosine for the P3 phenylalanine suppressed chymotrypsin cleavage of the P3-P2 bond.