1092355-71-9

Basic information

• Product Name: N-(2-formylphenyl)-4-nitrobenzamide
• Synonyms: N-(2-formylphenyl)-4-nitrobenzamide
• CAS NO: 1092355-71-9
• Molecular Weight: 270.244
• Mol File: 1092355-71-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-(2-formylphenyl)-4-nitrobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-formylphenyl)-4-nitrobenzamide(1092355-71-9)
• EPA Substance Registry System: N-(2-formylphenyl)-4-nitrobenzamide(1092355-71-9)

Safety Data

• Hazardous Substances Data: 1092355-71-9(Hazardous Substances Data)

Upstream product

• 26908-34-9 N-(2-(1,3-dioxolan-2-yl))phenylamine 
• 122-04-3 4-nitro-benzoyl chloride 
• 100-52-7 benzaldehyde 
• 2733-41-7 4-nitrobenzoyl azide 
• 51608-60-7 phenyl N-tosyl imine 
• 5344-90-1 2-Aminobenzyl alcohol 

Downstream Products

• 1309272-97-6 N-benzyl-N-(2-formylphenyl)-4-nitrobenzamide 
• 1309273-04-8 1-benzyl-2-(4-nitrophenyl)-1H-indol-3-yl benzoate 

Relevant articles and documents

Synthesis and Anti-inflammatory Evaluation of 2-Aminobenzaldehydes via Ir(III)-Catalyzed C-H Amidation of Aldimines with Acyl Azides

The aldimine-directed C-H amidation of various arenes with N-acyl azides as amidation surrogates under cationic iridium(III) catalysis is described. This transformation efficiently provides a range of 2-aminobenzaldehyde derivatives with excellent site selectivity and functional group compatibility. The resulting 2-aminobenzaldehyde framework provides facile access to a range of biologically interesting heterocycles. In addition, all synthetic compounds were screened for anti-inflammatory activity against interleukin-1β (IL-1β) and tumor necrosis factor alpha (TNF-α) with lipopolysaccharide (LPS)-induced RAW264.7 cells. Generally, a range of ortho-amidated benzaldehydes displayed promising inhibitory activity against IL-1β and TNF-α compared to dexamethasone as a positive control. Notably, compounds (3ae and 4ac) were found to exhibit potent anti-inflammatory activity stronger than that of dexamethasone.

Rh-catalyzed Transient Directing Group Promoted C—H Amidation of Benzaldehydes Utilizing Dioxazolones

Transition-metal catalyzed C—H functionalization of benzaldehydes is of great interest in organic synthesis. Herein, we developed a transient directing group assisted amidation of benzaldehydes catalyzed by rhodium catalyst. With the employment of 10 mol% of 4-trifluoromethyl aniline, the in situ generated imine groups as the directing group efficiently enable this transformation. By using this protocol, a wide range of benzaldehydes were efficiently converted into the corresponding N-(2-formylphenyl)benzamides utilizing dioxazolones as the nitrogen source.

Design and synthesis of novel N-benzylidenesulfonohydrazide inhibitors of murC and murD as potential antibacterial agents

A series of novel N-benzylidenesulfonohydrazide compounds were designed and synthesized as inhibitors of UDP-N-acetylmuramic acid:L-alanine ligase (MurC) and UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase (MurD) from E. coli, involved in the biosynthes