1092380-04-5

Basic information

• Product Name: C₂₁H₂₁F₃N₂O₆S
• CAS NO: 1092380-04-5
• Molecular Weight: 486.469
• Mol File: 1092380-04-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₂₁F₃N₂O₆S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₂₁F₃N₂O₆S(1092380-04-5)
• EPA Substance Registry System: C₂₁H₂₁F₃N₂O₆S(1092380-04-5)

Safety Data

• Hazardous Substances Data: 1092380-04-5(Hazardous Substances Data)

Upstream product

• 874-84-0 2-(2-nitroethenyl)thiophene 
• 76292-78-9 2-{[1-(4-Trifluoromethyl-phenyl)-meth-(Z)-ylidene]-amino}-malonic acid diethyl ester 

Relevant articles and documents

Thiourea-catalyzed asymmetric formal [3+2] cycloaddition of azomethine ylides with nitroolefins

A chiral thiourea catalyst possessing an amine function catalyzes an asymmetric [3+2] cycloaddition of azomethine ylides to nitroolefins to provide highly functionalized pyrrolidines with high diastereo- and enantioselectivities (up to 98:1:1 dr, 92% ee). The reaction proceeds in a stepwise manner consisting of Michael addition and subsequent intramolecular aza-Henry reaction. Both reactions are promoted by the thiourea catalyst, and the reaction rate of the latter step is efficiently enhanced by the addition of 2,2,2-trifluoroethanol.