1092486-06-0

Basic information

• Product Name: C₂₃H₂₀BrN₅O₃S
• Synonyms: C₂₃H₂₀BrN₅O₃S
• CAS NO: 1092486-06-0
• Molecular Weight: 526.413
• Mol File: 1092486-06-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₂₃H₂₀BrN₅O₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₂₀BrN₅O₃S(1092486-06-0)
• EPA Substance Registry System: C₂₃H₂₀BrN₅O₃S(1092486-06-0)

Safety Data

• Hazardous Substances Data: 1092486-06-0(Hazardous Substances Data)

Upstream product

• 7311-63-9 5-bromothiophene-2-carboxylic acid 
• 658700-12-0 N-[2-amino-1-(3-amino-3-oxopropyl)-1H-benzimidazol-5-yl]-N-methylbenzamide 

Downstream Products

• 1092486-39-9 C₂₅H₂₃N₅O₃S 

Relevant articles and documents

2-Aminobenzimidazoles as potent ITK antagonists: trans-stilbene-like moieties targeting the kinase specificity pocket

Based on the information from molecular modeling and X-ray crystal structures, the kinase specificity pocket of ITK could be occupied upon extension of the right-hand-side of the 2-benzimidazole core of the inhibitors. 2-Aminobenzimidazoles with a trans-stilbene-like extension were designed and synthesized as novel ITK antagonists. Significant improvement on binding affinity and cellular activity were obtained through the trans-stilbene-like antagonists. Several compounds showed inhibitory activity in an IL-2 functional assay.