1093098-96-4

Basic information

• Product Name: methyl 3-(1-(3-(3-(tert-butoxycarbonylamino)propoxy)-4-(4-isopropoxythiazol-2-yl)phenyl)-1H-imidazol-2-yl)propanoate
• Synonyms: methyl 3-(1-(3-(3-(tert-butoxycarbonylamino)propoxy)-4-(4-isopropoxythiazol-2-yl)phenyl)-1H-imidazol-2-yl)propanoate
• CAS NO: 1093098-96-4
• Molecular Weight: 544.672
• Mol File: 1093098-96-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl 3-(1-(3-(3-(tert-butoxycarbonylamino)propoxy)-4-(4-isopropoxythiazol-2-yl)phenyl)-1H-imidazol-2-yl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3-(1-(3-(3-(tert-butoxycarbonylamino)propoxy)-4-(4-isopropoxythiazol-2-yl)phenyl)-1H-imidazol-2-yl)propanoate(1093098-96-4)
• EPA Substance Registry System: methyl 3-(1-(3-(3-(tert-butoxycarbonylamino)propoxy)-4-(4-isopropoxythiazol-2-yl)phenyl)-1H-imidazol-2-yl)propanoate(1093098-96-4)

Safety Data

• Hazardous Substances Data: 1093098-96-4(Hazardous Substances Data)

Upstream product

• 178388-79-9 3-(1H-imidazol-2-yl)propanoic acid 
• 1093098-94-2 methyl 3-(1-(3-(3-(tert-butoxycarbonyl amino)propoxy)-4-cyanophenyl)-1H-imidazol-2-yl) propanoate 
• 1093098-93-1 tert-butyl 3-(5-bromo-2-cyanophenoxy)propylcarbamate 
• 58885-58-8 N-tert-butoxycarbonyl-3-aminopropanol 
• 105942-08-3 4-bromo-6-fluorobenzonitrile 
• 105-48-6 isopropyl chloroacetate 
• 1093098-95-3 methyl 3-(1-(3-(3-(tert-butoxycarbonyl amino)propoxy)-4-carbamothioylphenyl)-1H-imidazol-2-yl) propanoate 

Downstream Products

• 1093098-97-5 3-(1-(3-(3-(tert-butoxycarbonylamino)propoxy)-4-(4-isopropoxythiazol-2-yl)phenyl)-1H-imidazol-2-yl)propanoic acid 
• 1421328-79-1 3-(1-(3-(3-aminopropoxy)-4-(4-isopropoxythiazol-2-yl) phenyl)-1H-imidazol-2-yl) propanoic acid 
• 1421328-80-4 3-(1-(3-(3-aminopropoxy)-4-(4-phenylthiazol-2-yl) phenyl)-1H-imidazol-2-yl) propanoic acid 
• 1421328-65-5 methyl 3-(1-(3-(3-aminopropoxy)-4-(4-isopropoxythiazol-2-yl)phenyl)-1H-imidazol-2-yl)propanoate 

Relevant articles and documents

Expedient route to functionalized and water soluble 5-6-5 imidazole-phenyl-thiazole based α-helix mimetics

A range of small molecule scaffolds have been shown to act as structural and functional mimics of α-helices by mimicking the i, i+4, and i+7 positions, often found at the interface of PPIs. These molecules, though potent, possess complicating features - either low water solubility, or maintenance of conformation by hydrogen-bonding networks. We have addressed these limitations by developing a scaffold with increased water solubility. Herein we present a rapid synthetic pathway to a library of 56 compounds based on a 5-6-5 scaffold, containing an imidazole-phenyl-thiazole core; the route is flexible and allows rapid installation of different substituents via high-yielding Ullman and Suzuki couplings and Hantsch thiazole syntheses.