109329-68-2

Basic information

• Product Name: dimethyl 4-(2-chlorophenyl)-1,2,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate
• CAS NO: 109329-68-2
• Molecular Weight: 349.814
• Mol File: 109329-68-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: dimethyl 4-(2-chlorophenyl)-1,2,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl 4-(2-chlorophenyl)-1,2,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate(109329-68-2)
• EPA Substance Registry System: dimethyl 4-(2-chlorophenyl)-1,2,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate(109329-68-2)

Safety Data

• Hazardous Substances Data: 109329-68-2(Hazardous Substances Data)

Upstream product

• 67593-46-8 methyl 2-(2-chlorophenylmethylene)acetoacetate 
• 13412-12-9 3-methylaminobut-2-enoic acid methyl ester 
• 89-98-5 2-chloro-benzaldehyde 
• 105-45-3 acetoacetic acid methyl ester 
• 74-89-5 methylamine 

Downstream Products

• 109346-07-8 3-Aza-1,5-dicarbomethoxy-9-(2-chlorophenyl)-3-methyl-2,4-dimethylenebicyclo<3.3.1>nonane 

Relevant articles and documents

Synthesis and radioprotective effects of adamantyl substituted 1,4-dihydropyridine derivatives

A series of 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diesters substituted at the N-1 and/or C-4 positions of the dihydropyridine ring was synthesized. The in vitro cytotoxicity and in vitro and in vivo radioprotective efficacy of these agents were evaluated in Chinese hamster (V-79) cells and CD2F1 male mice, respectively. Compounds with at least one adamantyl substituent afforded better radioprotection than those without this substituent. Substitution of an aromatic ring at the C-4 position of the dihydropyridine ring did not enhance the radioprotectant action of the compounds. Copyright (C) 1998 Elsevier Science Ltd.

1,4- DIHYDROPYRIDINE DERIVATIVES WITH HSP MODULATING ACTIVITY

The invention provides 1,4-dihydropyridine derivatives of formula (I) wherein R1 is optionally substituted C6-24aryl group or 5 to 6 membered heteroaryl group comprising 1 to 3 nitrogen atoms or other heteroatoms like oxygen and sulp