1093880-37-5 Usage
Description
6-Chloro-2-fluoropyridine-3-carboxaldehyde is an organic compound characterized by its unique molecular structure featuring a pyridine ring with a chloro and fluoro substituent at the 6th and 2nd positions, respectively. It possesses a carboxaldehyde functional group at the 3rd position, which grants it reactivity and versatility in various chemical reactions. 6-Chloro-2-fluoropyridine-3-carboxaldehyde is a valuable intermediate in the synthesis of complex organic molecules and pharmaceuticals due to its distinct structural features and reactivity.
Uses
Used in Pharmaceutical Synthesis:
6-Chloro-2-fluoropyridine-3-carboxaldehyde is used as a key reactant in the synthesis of various pharmaceutical compounds. Its unique structural features and reactivity make it a promising candidate for the development of new drugs with improved therapeutic properties.
Used in Organic Chemistry Research:
In the field of organic chemistry, 6-Chloro-2-fluoropyridine-3-carboxaldehyde serves as an important building block for the synthesis of complex organic molecules. Its reactivity and structural diversity allow researchers to explore novel reaction pathways and develop innovative synthetic strategies.
Used in the Synthesis of Phantasmidine:
6-Chloro-2-fluoropyridine-3-carboxaldehyde is used as a reactant in the synthesis of phantasmidine, a complex organic molecule, through a tandem intramolecular aldol reaction-intramolecular nucleophilic aromatic substitution sequence. This process results in the formation of the tetracyclic lactam, which is a crucial intermediate in the synthesis of phantasmidine and other related compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 1093880-37-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,9,3,8,8 and 0 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1093880-37:
(9*1)+(8*0)+(7*9)+(6*3)+(5*8)+(4*8)+(3*0)+(2*3)+(1*7)=175
175 % 10 = 5
So 1093880-37-5 is a valid CAS Registry Number.
1093880-37-5Relevant articles and documents
Synthesis of phantasmidine
Zhou, Quan,Snider, Barry B.
, p. 526 - 529 (2011)
Reaction of 6-chloro-2-fluoro-3-pyridineacetamide with 1,2- bis(trimethylsilyloxy)cyclobutene in ether saturated with hydrogen chloride afforded the keto amide in 85% yield. In the key step, treatment of the keto amide with aqueous KOH in t-BuOH resulted in a tandem intramolecular aldol reaction-intramolecular nucleophilic aromatic substitution sequence to give the tetracylic lactam in 46% yield. Reduction of the lactam with BH3 in THF gave phantasmidine in 67% yield.
TRICYCLIC PIPERIDINE COMPOUNDS
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Page/Page column 112-113, (2015/06/08)
The present invention relates to compounds of the formula (I), wherein R, R1a, R1b, R2, R3, and X are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), to methods for the preparation of such compounds of formula (I), and especially to their use as TPH modulators.
PREPARATION OF PHANTASMIDINE AND ANALOGUES THEREOF
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Page/Page column 30-31, (2012/06/30)
Described are methods of synthesizing phantasmidine and analogues thereof from commercially available starting materials. The compounds are useful as pharmacological probes and potential lead compounds for the development of selective nicotinic receptor therapeutics.
