1093980-57-4

Basic information

• Product Name: 1H-IMidazole, 1-(4-ethynyl-2-Methoxyphenyl)-4-Methyl-
• Synonyms: 1H-IMidazole, 1-(4-ethynyl-2-Methoxyphenyl)-4-Methyl-;1-(4-ethynyl-2-methoxyphenyl)-4-methyl-1H-imidazole
• CAS NO: 1093980-57-4
• Molecular Formula: C₁₃H₁₂N₂O
• Molecular Weight: 212.24718
• Mol File: 1093980-57-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-IMidazole, 1-(4-ethynyl-2-Methoxyphenyl)-4-Methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-IMidazole, 1-(4-ethynyl-2-Methoxyphenyl)-4-Methyl-(1093980-57-4)
• EPA Substance Registry System: 1H-IMidazole, 1-(4-ethynyl-2-Methoxyphenyl)-4-Methyl-(1093980-57-4)

Safety Data

• Hazardous Substances Data: 1093980-57-4(Hazardous Substances Data)

Usage

General Description

1H-Imidazole, 1-(4-ethynyl-2-methoxyphenyl)-4-methyl- is a chemical compound with the molecular formula C13H11N. It is a derivative of imidazole, containing a 4-ethynyl-2-methoxyphenyl and a 4-methyl substituent. 1H-Imidazole, 1-(4-ethynyl-2-methoxyphenyl)-4-methyl- is a heterocyclic aromatic organic compound with potential applications in medicinal and pharmaceutical research. It has been studied for its potential biological activities and therapeutic properties, including its role as a potential inhibitor of enzyme activity and as a modulator of signaling pathways. However, further research and studies are needed to fully understand the properties and potential applications of this chemical compound.

Upstream product

• 870837-18-6 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde 
• 90965-06-3 dimethyl 1-(1-diazo-2-oxopropyl)phosphonate 
• 128495-46-5 4-fluoro-3-methoxybenzaldehyde 

Downstream Products

• 1093975-89-3 1-[3,5-bis(trifluoromethyl)benzyl]-4-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1H-1,2,3-triazole 
• 1093975-91-7 1-(3,5-di-tert-butylbenzyl)-4-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1H-1,2,3-triazole 
• 1093976-02-3 4-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-[3-(trifluoromethyl)benzyl]-1H-1,2,3-triazole 
• 1093975-82-6 1-(3-fluorobenzyl)-4-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1H-1,2,3-triazole 
• 1093976-07-8 4-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1-[3-(trifluoromethoxy)benzyl]-1H-1,2,3-triazole 
• 1093976-10-3 1-(3,5-dibromobenzyl)-4-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1H-1,2,3-triazole 
• 1093975-68-8 8-({4-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1H-1,2,3-triazol-1-yl}methyl)quinoline 
• 1315141-37-7 C₂₃H₂₁N₇O 
• 1093975-72-4 3-[3-({4-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1H-1,2,3-triazol-1-yl}methyl)phenyl]-5-methyl-1,2,4-oxadiazole 
• 1093975-74-6 3-[4-({4-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1H-1,2,3-triazol-1-yl}methyl)phenyl]-5-methyl-1,2,4-oxadiazole 
• 1093975-99-5 4-{3-[4-({4-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1H-1,2,3-triazol-1-yl}methyl)phenyl]-1,2,4-oxadiazol-5-yl}pyridine 
• 1315141-38-8 C₂₂H₁₉N₅OS 
• 1315141-39-9 C₂₂H₁₉N₅OS 
• 1093975-49-5 2-(4-{4-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]-[1,2,3]triazol-1-ylmethyl}phenyl)benzooxazole 

Relevant articles and documents

Discovery of novel triazolobenzazepinones as γ-secretase modulators with central Aβ42 lowering in rodents and rhesus monkeys

Abstract Synthesis and SAR studies of novel triazolobenzazepinones as gamma secretase modulators (GSMs) are presented in this communication. Starting from our azepinone leads, optimization studies toward improving central lowering of Aβ42 led to the discovery of novel benzo-fused azepinones. Several benzazepinones were profiled in vivo and found to lower brain Aβ42 levels in Sprague Dawley rats and transgenic APP-YAC mice in a dose-dependent manner after a single oral dose. Compound 34 was further progressed into a pilot study in our cisterna-magna-ported rhesus monkey model, where we observed robust lowering of CSF Aβ42 levels.

Triazoles as γ-secretase modulators

Synthesis, SAR, and evaluation of aryl triazoles as novel gamma secretase modulators (GSMs) are presented in this communication. Starting from the literature and in-house leads, we evaluated a range of five-membered heterocycles as replacements for olefin